三味舒郁方抗抑郁的择时用药研究  

Anti-depressant effects of Sanweishuyu recipe by chrono-medication

作　　者：陈蓓[1] 胡剑北[1] 

机构地区：[1]皖南医学院中西医结合研究中心,安徽芜湖241002

出　　处：《皖南医学院学报》2010年第3期179-182,共4页Journal of Wannan Medical College

基　　金：皖南医学院科研启动基金(WKR200702)

摘　　要：目的:研究三味舒郁方抗抑郁的择时用药。方法:通过小鼠悬尾实验、强迫游泳实验以及小鼠脑单胺氧化酶活性的测定,观察三味舒郁方在不同给药时间的抗抑郁作用。结果:三味舒郁方能明显缩短小鼠悬尾不动时间和强迫游泳不动时间,降低脑单胺氧化酶的活性(P<0.05或P<0.01)。结论:三味舒郁方有明显的抗抑郁作用,且在晨间给药的抗抑郁强度大于夕间给药。Objective：To investigate the antidepressant effects of Sanweishuyu recipe by chrono-medication.Methods：The antidepressant effects of Sanweishuyu recipe were measured concerning chrono-medication by the two behavioral despair experiments of mouse tail suspension and forced swimming test and determination of the monoamine oxidase（MAO）activity in the brain of mice.Results：Sanweishuyu recipe significantly reduced the duration of immobility of tail suspension and forced swimming and the activity of MAO as well（P0.05 or P0.01）.Conclusion：Sanweishuyu recipe can evidently be effective in anti-depression,and it functions better in morning hours than at dusk.

关 键 词：三味舒郁方 中药提取物 抗抑郁 择时用药 

分 类 号：R749.41[医药卫生—神经病学与精神病学]