施捷因对脑出血患者血清S-100β蛋白与神经元特异性的影响  

Influence of GM-1 on the expression of S-100β protein and NSE in patients with cerebral hemorrhage

作　　者：刘洪杰[1] 苏建 

机构地区：[1]河南周口市中心医院急诊科,周口466300 [2]河南开封市第一人民医院神经内科,开封475100

出　　处：《中国实用神经疾病杂志》2010年第10期32-33,共2页Chinese Journal of Practical Nervous Diseases

摘　　要：目的探讨施捷因对脑出血患者血清S-100β蛋白与神经元烯醇化酶(NSE)表达水平的影响。方法采用酶联免疫吸附法对32例脑出血患者起病1、3、7d血清S-100β蛋白与NSE水平进行动态测定。结果脑出血患者血清S-100β蛋白与NSE浓度在起病1、3、7d均显著升高,经施捷因治疗后表达水平明显下降,与脑出血组比较,差异有统计学意义(P<0.01)。结论施捷因可以显著减轻脑出血患者的神经损伤。Objective To explore the influence of GM-1 on the expression of S-100β protein and NSE in patients with cerebral hemorrhage.Methods The serum S-100β protein and NSE in 32 patients with cerebral hemorrhage were tested by ELISA at 1st,3rd and 7th day after the hemorrhage happened.Results The serum S-100β protein and NSE values at 1st,3rd and 7th day after the hemorrhage occurred were higher than those of GM-1 treated group （P0.01）.Conclusion The serum S-100β protein and NSE test in patients with cerebral hemorrhage are very useful in judging the severity and prognosis.

关 键 词：施捷因 脑出血 S-100Β蛋白 神经元烯醇化酶 神经损伤 

分 类 号：R743.34[医药卫生—神经病学与精神病学]