康泰复方对D-IBS患者结肠黏膜HO-1和iNOSmRNA表达的影响  

Effect of kangtai on the HO-1 and iNOS mRNA in colonic mucosa with D-IBS

作　　者：于丰彦[1] 陶双友[2] 罗琦[2] 周福生[2] 廖荣鑫[2] 

机构地区：[1]南方医科大学珠江医院,广东广州510280 [2]广州中医药大学脾胃研究所,广东广州510405

出　　处：《海南医学》2010年第10期9-12,共4页Hainan Medical Journal

基　　金：广东省中医药管理局科研课题资助(编号:1060080)

摘　　要：目的观察疏肝健脾安神和胃法的康泰方对肝郁脾虚型D-IBS患者治疗前、后结肠黏膜HO-1和iNOSmRNA的表达的影响,从结肠粘膜HO-1和iNOSmRNA的方面初步探讨康泰方治疗D-IBS的可能机制。方法采用随机分组法将63例受试对象分为治疗组(32例)和对照组(31例),观察治疗前、后结肠粘膜HO-1和iNOSmRNA表达的变化,并分别与15例健康对照组进行比较。结果治疗组治疗前、后HO-1和iNOSmRNA的表达差异有统计学意义(P<0.05),对照组治疗前、后的HO-1和iNOSmRNA的表达差异亦有统计学意义(P<0.05)。结论结肠黏膜HO-1和iNOSmRNA表达可能是其临床表现的致病机理,康泰方可通过上述机理改善临床症状。Objective To observe the effect of kangtai on the HO-1 and iNOS mRNA in colonic mucosa with D-IBS.Methods 63 cases were randomly divided into the treatment group and the control group,and the treatment group and control group had been treated with kangtai,and pinaverium bromide tablets for 8 weeks,respectively.The expression of HO-1 and iNOS mRNA were detected in colonic mucosa before and after treatment.Results There was a significant difference of the expression of HO-1 and iNOS mRNA in colonic mucosa between before and after treatment.Conclusion The expression of HO-1 and iNOS mRNA in colonic mucosa may be the pathogenesis of D-IBS,and kangtai can improve symptoms via the above-mentioned mechanisms.

关 键 词：肝郁脾虚型 D-IBS HO-1mRNA INOSMRNA 

分 类 号：R574[医药卫生—消化系统]