204例胰腺癌患者生存分析  

Survival analysis of 204 patients with pancreatic cancer

作　　者：张德祥[1] 袁苏徐[2] 戴月娣[3] 

机构地区：[1]复旦大学附属金山医院普外科,上海200540 [2]苏州大学附属第一医院肿瘤科 [3]复旦大学附属肿瘤医院闵行分院肿瘤科

出　　处：《中华消化杂志》2010年第4期236-240,共5页Chinese Journal of Digestion

摘　　要：目的观察胰腺癌患者临床特征、血常规、生化指标对预后的影响。方法电话随访病理诊断明确为胰腺癌患者的生存期，收集临床特征、血常规、生化指标，分析资料齐全的204例患者各因素对预后的影响。结果204例胰腺癌患者1、2、3年生存率分别为32．8％、13．7％、2．9％，中位生存期为6．4个月。单因素分析显示未手术治疗患者较行根治性切除术或姑息手术患者的生存期短（P〈0．01）；肿瘤标志物高、血红蛋白低、白细胞高、血清白蛋白低、血清肌酐水平高的患者生存期短（P〈0．01）；丙氨酸转氨酶及天冬氨酸转氨酶高的患者较正常患者生存期长（P〈0．05）。COX回归分析显示分期晚的患者生存时间短（P〈0．01）；血清白蛋白低、血清肌酐高患者生存时间短（P〈0．05）。结论手术、临床分期、肿瘤标志物水平、血红蛋白、白细胞、血清白蛋白、血清肌酐均为影响胰腺癌患者预后的独立危险因素。Objective To investigate the impacts of clinical features, blood and biochemical parameters on survival of patients with pancreatic cancer. Methods Two hundred and four patients with pathologically performed pancreatic cancer were retrospectively analyzed. All patients were followed-up by means of phone. Results The survival rate of 204 patients with pancreatic cancer was 32.8% at 1-year, 13.7% at 3-year and 2.9% at 5-year, with medium survival time of 6.4 months. Univariate examination showed that the long survival time was found in patients with radical or palliate operation in comparison with those without （P〈0.01）. The factors that impacted on the survival times were high tumor marker, .high serum creatinine, high white blood cells, low hemoglobin and low albumin （P〈0.01）. Whereas the patients with high levels of ALT and AST had long survival time （P〈0.05）. COX regression analysis revealed that those with advanced stage, low albumin and high creatinine had short survival time（P〈0.05）. Conclusions Surgery, tumor stage, tumor marker, hemoglobin, white blood cell, albumin and creatinine are independent prognostic factors.

关 键 词：胰腺癌 无病生存 回顾性研究 

分 类 号：R735.9[医药卫生—肿瘤]