幽门螺杆菌感染者IL-1β分泌与糜烂性食管炎的关系  

Association between interleukin-1β production and erosive esophagitis in Helicobacter pylori-infected patients

作　　者：章菲菲[1] 瞿玲玲[1] 曹广亚[2] 许子倩 吕鸣[1] 吕有灵 

机构地区：[1]武警上海总队医院消化科,上海市201103 [2]武警上海总队医院检验科,上海市201103

出　　处：《世界华人消化杂志》2010年第14期1489-1491,共3页World Chinese Journal of Digestology

摘　　要：目的:分析H.pylori感染者中IL-1β表达与糜烂性食管炎(EE)发生的关系,探索H.pylori感染者中EE发生减少的机制.方法:收集2007-05/2009-05武警上海总队医院行胃镜检查者(排除消化性溃疡和消化系肿瘤患者)共456例,行H.pylori和胃窦黏膜活检组织IL-1β检测.结果:根据Los Angeles食管炎分级系统诊断反流性食管炎141例.H.pylori阳性组中EE的发生率(39/302,12.9%,95%CI:9.1%-16.9%)显著低于H.pylori阴性组(102/154,66.2%,95%CI:58.4%-73.0%)(P=0.000).H.pylori阳性组胃窦活检组织中IL-1β表达明显高于H.pylori阴性组(P=0.007),而且H.pylori阳性组中合并EE患者的IL-1β表达量较不合并EE者低(P=0.032).结论:H.pylori感染对EE发生的"保护"机制可能与IL-1β表达有关.AIM：To explore the mechanism underlying the lower prevalence of gastroesophageal reflux disease in Helicobacter pylori（H.pylori）-infected patients by analyzing the association between interleukin-1β（IL-1β） production and erosive esophagitis（EE） in H.pylori-infected patients.METHODS：A total of 456 consecutive dyspeptic patients without peptic ulcer or cancer were included in the study.EE was assessed endoscopically.H.pylori infection was diagnosed by 14 Curea breath test,rapid urease test and histological examination.The level of IL-1β production in gastric mucosa was detected by radioimmunoassay.RESULTS：Three hundred and two patients were positive and 154 were negative for H.pylori.One hundred and forty-one patients were found to have EE according to endoscopic criteria（Los Angeles classification of esophagitis）.The prevalence of EE in H.pylori-positive patients（39/302,12.9%;95%CI：9.1%-16.9%） was significantly lower than that in H.pylori-negative ones（102/154,66.2%;95%CI：58.4%-73.0%;P=0.000）.The level of IL-1β in H.pylori-positive patients was higher than that in H.pylori-negative ones（P=0.007）.In H.pylori-positive patients,the level of IL-1β production in EE patients was lower than that in those without EE（P=0.032）.CONCLUSION：The＂protective＂mechanism of H.pylori infection against EE is probably associated with IL-1β production.

关 键 词：幽门螺杆菌 食管炎 白介素-1 

分 类 号：R571[医药卫生—消化系统]