残胃粘膜屏障损伤与残胃癌前病变关系的实验研究  

EXPERIMENTAL STUDY ON THE RELATION BETWEEN THE DAMAGE OF GASTRIC REMNANT MUCOSAL BARRIER AND THE PRECANCEROUS LESION OF GASTRIC REMNANT MUCOSA AFTER SUBTOTAL GASTRECTOMY

作　　者：汤礼军[1,2] 田伏洲[1,2] 麻晓林 周丁华[1,2] 晏才杰 

机构地区：[1]成都军区总医院全军腹部外科中心 [2]第三军医大学新桥医院普通外科

出　　处：《中国普外基础与临床杂志》1999年第1期7-10,共4页Chinese Journal of Bases and Clinics In General Surgery

摘　　要：为研究胃大部切除术后残胃粘膜屏障损伤与残胃粘膜癌前病变的关系，在甲基硝基亚硝基胍（ＮｍｅｔｈｙＮ’ｎｉｔｒｏＮｎｉｔｒｏｓｏｇｕａｎｉｄｉｎｅ，ＭＮＮＧ）诱发犬残胃粘膜癌前病变过程中，胃镜下定期行残胃粘膜活检的同时，对跨胃粘膜电位差（ｇａｓｔｒｉｃｔｒａｎｓｍｕｃｏｓａｌｐｏｔｅｎｔｉａｌｄｉｆｅｒｅｎｃｅ，ＧＴＰＤ）及粘膜细胞核ＤＮＡ含量进行了动态测定。结果：随着残胃吻合口粘膜病变加重，ＧＴＰＤ值呈渐进性下降趋势，且ＧＴＰＤ值与相应粘膜细胞核ＤＮＡ含量之间呈显著负相关关系。本实验结果提示：随着残胃粘膜屏障损伤程度的加重，粘膜组织细胞恶变潜能就越大；残胃粘膜屏障损伤在残胃癌前病变发生过程中起着至关重要的作用。To find the relation between the damage of gastric remnant mucosal barrier and the precancerous lesion of gastric remnant mucosa, in the process of the canine gastric remnant precarcinogenesis induced by N methy N' nitro N nitrosoguanidine (MNNG), we performed regularly the esophagogastroscopy and the mucosal biopsy.At the same time, we also measured gastric transmucosal potential difference and intracellular DNA content of remnant mucosa.We found that the more severe the damage of gastric remnant mucosal barrier was , the greater the malignant capacity of gastric remnant mucosal was.Our study suggests that the damage of gastric remnant mucosal barrier plays an important role in the gastric remnant mucosal precarcinogenesis.

关 键 词：残胃粘膜 癌前病变 粘膜屏障损伤 

分 类 号：R735.202[医药卫生—肿瘤]