鼻咽癌survivin、Bcl-2及nm23-H1的表达与^(18)F-FDG PET标准化摄取值的关系  

Relations between the expression of survivin,Bcl-2,nm23-H1 and the standardized uptake value (SUV) of ^(18)F-fluorodeoxyglucose in NPC

作　　者：黎静[1] 潘艳东[1] 李志强[1] 郭晓彤[2] 李陆振[2] 尹吉林[2] 陈晓东[2] 李向东[2] 王卓才[2] 陈炳旭[2] 张伟[2] 陈敬文[2] 

机构地区：[1]广州军区广州总医院肿瘤科,广州510010 [2]广州军区广州总医院病理科,广州510010

出　　处：《广东医学》2010年第9期1106-1108,共3页Guangdong Medical Journal

摘　　要：目的探讨鼻咽癌(NPC)survivin、Bcl-2及nm23-H1的表达与18F-FDGPET标准化摄取值(SUV)的关系。方法 32例经病理组织学确诊的初治NPC患者于治疗前均行全身18F-脱氧葡萄糖PET显像,测定平均SUV值,鼻咽活检病理标本经常规石蜡切片,用免疫组织化学技术检测肿瘤组织survivin、Bcl-2及nm23-H1的表达,计算survivin、Bcl-2及nm23-H1阳性表达百分数。结果 (1)NPC中survivin阳性表达率为69%(22/32),Survivin阳性患者平均SUV值与阴性患者比较差异无统计学意义(7.68±1.64vs6.87±1.01,P>0.05);(2)NPC中Bcl-2阳性表达率为72%(23/32),Bcl-2阳性患者平均SUV值与阴性患者比较差异无统计学意义(7.21±1.45vs7.16±2.55,P>0.05);(3)NPC中nm23-H1阳性表达率为56%(18/32),nm23-H1阳性患者平均SUV值较阴性患者明显降低(5.90±1.06vs8.07±1.43),差异有统计学意义(P<0.01)。结论 NPC中存在survivin、Bcl-2、nm23-H1高表达;Survivin、Bcl-2阳性表达与SUV值无相关性,nm23-H1阳性表达与SUV值具有相关性。Objective To investigate the correlation between the expression of Survivin,Bcl-2,nm23-H1 and the SUV of FDG in NPC. Methods Thirty two patients with NPC comfirmed by biopsy but without previous treatment were evaluated with ^18F-FDG PET/CT examination for calculation of SUV. The positive expression rates of Survivin,Bcl-2 and nm23-H1 were assessed by immunohistochemistry. Results （1） The positive expression rate of Survivin was 68.7%（22/32）.There was no significant difference of SUV between Survivin positive and Survivin negative patients （P〈0.05）.（2） The positive expression rate of Bcl-2 was 72%（23/32）. There was no significant difference of SUV between Bcl-2 positive and Bcl-2 negative patients （P〈0.05）. （3） The positive expression rate of nm23-H1 was 56.3 %（18/32）. The SUV was significantly lower in nm23-H1 positive patients than that in the negative ones （P〈0.01）. Conclusion （1） The expression of Survivin,Bcl-2 and nm23-H1 was elevated in NPC. （2） There is significant correlation between nm23-H1 positive expression and SUV,but there is no correlation between Survivin,Bcl-2 positive expression and SUV.

关 键 词：正电子发射层计算机断层显像 18F-氟-脱氧葡萄糖 标准化摄取值 SURVIVIN BCL-2 NM23-H1 免疫组织化学 

分 类 号：R738.1[医药卫生—肿瘤]