高分级脑胶质瘤术后放疗同步替尼泊甙联合司莫司汀化疗疗效分析  

Effect of Postoperative Radiotherapy Concurrent Chemotherapy on Patients with High-grade Cerebral Gliomas

作　　者：王建平[1] 翟小明[1] 顾科[1] 张军宁[1] 

机构地区：[1]苏州大学附属第一医院放疗科,江苏苏州215006

出　　处：《苏州大学学报（医学版）》2010年第2期384-387,共4页Suzhou University Journal of Medical Science

摘　　要：目的分析高分级脑胶质瘤患者术后同步放化疗的疗效。方法对该院收治的65例高分级脑胶质瘤术后患者(其中Ⅲ级脑胶质瘤37例,Ⅳ级28例)均给予术后放疗肿瘤剂量(DT)50～60Gy,同时于DT20Gy后行同步替尼泊甙(VM-26)联合司莫司汀(Me-CCNU)化疗,于放疗开始后4～6个月内完成4～6周期的化疗。结果高分级脑胶质瘤患者总的中位生存期为24个月,1、3、5年生存率分别为70.77%、31.22%、12.65%。Ⅳ级胶质瘤生存率明显低于Ⅲ级胶质瘤(P(0.01),Ⅳ级与Ⅲ级脑胶质瘤的中位生存期分别为14个月及36个月,1、3、5年生存率分别为60.71%、8.04%、0及78.38%、48.03%、21.76%。结论高分级脑胶质瘤患者术后行放疗同步VM-26联合Me-CCNU方案化疗可取得较好的预后,尤其是Ⅲ级脑胶质瘤患者。Objective To retrospectively study the prognoses of patients with high-grade cerebral gliomas received concurrent radiochemotherapy postoperatively.Methods Sixty-five postoperative patients with high-grade cerebral gliomas were treated.They were irradiated with DT50～60Gy combined with chemotherapy（VM-26 and Me-CCNU） after DT20Gy.And 4～6 cycles of chemotherapy were delivered within 4～6 months after the beginning of irradiation.Results The overall median survival time was 24 months and the 1-,3-,and 5-year survival rate of these patients was 70.77%、31.22% and 12.65%.The 1-,3-,and 5-year survival rate of patients with Ⅲ or Ⅳ grade cerebral gliomas was 78.38%,48.03%,21.76% and 60.71%,8.04%,0 respectively.The difference of the survival rates between patients with Ⅲ and Ⅳ grade gliomas was significant（P﹤0.01） and the median survival time was 36 months and 14 months respectively.Conclusion Given concurrent radiochemotherapy postoperatively,the survival rate may be rather high in patients with high-grade cerebral gliomas,especially in Ⅲ grade cases.And VM-26 combined with Me-CCNU could be an effective chemotherapeutic scheme.

关 键 词：脑 高分级胶质瘤 放射治疗 化学治疗 

分 类 号：R739.410.5[医药卫生—肿瘤]