透明质酸酶诱导兔颞下颌关节骨关节病的实验研究  

OSTEOARTHROSIS OF THE TEMPOROMANDIBULAR JOJNT INDUCED BY HYALURONIDASE IN ADULT RABBITS

作　　者：陈慧芝[1] 陈欣然[1] 吴华辉 张志光 

机构地区：[1]广州市红十字会医院口腔科

出　　处：《北京口腔医学》1999年第1期7-9,共3页Beijing Journal of Stomatology

摘　　要：目的：建立兔颞下颌关节骨关节病动物模型。方法：将不同浓度透明质酸酶（ＨＤ）一次性注入两组兔颞下颌关节下腔内，分别于注射后２４ｈ，１、４、８、１２周后处死动物，对颞下颌关节标本进行组织学观察。结果：注射ＨＤ４周后出现关节表面软骨破坏，关节盘胶原纤维暴露，滑膜慢性炎症等骨关节病表现。结论：本实验研究建立的颞下颌关节骨关节病模型可用于颞下颌关节骨关节病早。Objective:To establish an animal of osteoarthrosis(OA) in the temporomandibular joint(TMJ) (TMJOA) by injecting hyaluronidase(HD)into the downer compartments of TMJs in adult rabbits.Methods:Adult rabbits were randomly divided into four groups of five animals each.C and D groups were used as control.In group A and group B HD was injected into the downer compartments at two different concentrations at a volume of 0.1ml.The samples of TMJs were analyzed histologically in four different times after injection.Results:The animals which had injected HD at different concentrations resulted in similar consequence.The typical changes of OA occurred in TMJ The damages were in early to moderate stage.No pathological changes could be found in TMJs of the control groups.Conclusion:The results suggest that HD may be of use in establishing the animal model of TMJOA.

关 键 词：颞下颌关节 骨关节病 透明质酸酶 动物模型 

分 类 号：R782.602[医药卫生—口腔医学]