五加苷对大鼠脑梗死的保护作用  

Effect of acankoreoside A on prevention and treatment of focal cerebral infarction of rats

作　　者：刘向前[1,2] 邹亲朋[2] 冯胜[2] 郑礼胜[2] 陆昌洙[3] 

机构地区：[1]湖南中医药大学药学院,湖南长沙410208 [2]中南大学制药工程系,湖南长沙410083 [3]庆熙大学药学院生药学研究室

出　　处：《药物评价研究》2010年第2期95-97,共3页Drug Evaluation Research

基　　金：教育部留学回国人员科研启动基金(教外司留[2005]55号);湖南省教育厅中药学重点学科;湖南中医药大学十一五校级重点学科中药化学与分析资助

摘　　要：目的:研究五加苷对大鼠局灶性脑梗死的防治及对脑缺血模型大鼠脑梗死灶体积的影响。方法:对局灶性脑梗死的防治,采用栓线法造模,检测各组大鼠脑组织含水量,并观察脑组织形态学变化;对脑缺血模型大鼠脑梗死灶体积影响的研究,依据Zea-Longa栓线法造模,治疗组以五加苷ig,对照组用生理盐水代替五加苷,Swanson法测定脑梗死灶体积,并观察脑组织形态学变化。结果:经五加苷治疗的局灶性脑梗死大鼠的脑含水量降低,光学显微镜下观察脑组织形态学有明显改善;经五加苷治疗的脑缺血模型大鼠脑梗死灶体积显著降低。结论:五加苷对脑梗死大鼠有明显脑保护作用。Objective： To study the prevention and treatment of cerebral infarction in rats using acankoreoside A, and the effect of acankoreoside A on cerebral infarction volume in focal cerebral ischemia rat model. Methods： For the research of the prevention and treatment of focal cerebral infarction, the models of the focal cerebral infarction of the rats were made by putting the special thread to the internal carotid artery. The water content in the rats＇brain was detected, and the brain morphological changes were observed. For the study of the effect of acankoreoside A on cerebral infarction volume in focal cerebral ischemia rat model, the models of the focal cerebral infarction rats of the treated group and normal group were made according to Zea-Longa modeling filament method. The treated group rats were administrated with acankoreoside A and the normal group rats with normal saline. The cerebral infarction volumes were determined by Swanson method and the brain morphological changes were observed. Results： The results show that that the water content in the focal cerebral infarction rats＇ brain is significantly reduced, brain morphology is obviously improved though optical microscope observation, and cerebral ischemia infarct volume of focal cerebral ischemia rats is distinctly lower after treated with acankoreoside A. Conclusion： Acankoreoside A has significantly protective effect on cerebral infarction in rats.

关 键 词：五加苷 局灶性脑梗死 脑梗死灶体积 

分 类 号：R743.3[医药卫生—神经病学与精神病学]