DCC和Ki67在宫颈上皮内瘤变和宫颈癌中的表达及意义  

Expression and significance of DCC and Ki67 in cervical intraepithelial neoplasia and cervical cancer

作　　者：侯菊茹 金东岭[2] 刘现军[2] 王蕾[2] 

机构地区：[1]河北省永年县第一医院,057150 [2]河北工程大学医学院

出　　处：《河北医药》2010年第9期1043-1045,共3页Hebei Medical Journal

摘　　要：目的探讨大肠癌缺失基因(deleted in colorectal carcinoma gene,DCC)和Ki67在宫颈上皮内瘤变(cervical intraepithelial neoplasia,CIN)及宫颈癌组织中的表达及临床病理意义。方法采用免疫组化技术(SP法)检测DCC和Ki67在16例CIN和33例宫颈癌中的表达。结果 DCC和Ki67在慢性宫颈炎、CINⅠ～Ⅱ级、CINⅢ级和宫颈浸润癌组织中表达的阳性率分别为75.0%、50.0%、37.5%、24.2%和10.0%、43.8%、75.0%、87.9%。DCC在宫颈浸润癌和CINⅢ级组织中的表达显著低于慢性宫颈炎组织(P<0.05),其阳性表达率与年龄、临床分期及病理分级无关(P>0.05)。Ki67在宫颈浸润癌组织中阳性表达率显著高于CINⅠ～Ⅱ级和慢性宫颈炎组织(P<0.05);Ki67在各级CIN的阳性表达率显著高于慢性宫颈炎组织(P<0.05);Ki67表达率与临床分期及病理分级有关(P<0.05)。结论 DCC的检测有助于宫颈癌的早期诊断,而Ki67的检测则不仅有助于宫颈癌的早期诊断,而且还是监控子宫颈癌发展以及预后的判断的重要指标。Objective To investigate the expressions and clinical significance of DCC and Ki67 in cervical intraepithelial neoplasia（CIN） and cervical cancer. Methods Immunohistochemistry （SP method） was used to detect tbe expressions of DCC and Ki67 in 16 cases of CIN and 49 cases of cervical cancer. Results The positive expression rate of DCC and Ki67 in chronic cervicitis, CIN I - II, CIN Ⅲ and cervical cancer were 75.0% ,50.0% ,37.5% ,24.2% and 10.0% ,43.8% ,75. 0% ,87.9% respectively. The positive expression rate of DCC was significantly different between cervical cancer, CIN Ⅲ and chronic cervicitis （ P 〈 0. 05 ）. The positive expression rate of DCC was not related with age, clinical stage and pathologic grade of cervical cancer （P 〉 0. 05） . The expressions of Ki67 in CIN I - II , chronic cervicitis and cervical cancer were positively correlated with clinical stage and pathological grade of cervical cancer （ P 〈 0. 05 ）. Conclusion DCC test is helpful to the early diagnosis of cervical cancer, while the detection of Ki67 is not only contribute to the early diagnosis of cervical cancer, but also to monitor the development of cervical cancer, which also is an important indicator for patients ＇ prognosis.

关 键 词：大肠癌缺失基因 KI67 宫颈癌 宫颈上皮内瘤变 免疫组织化学 

分 类 号：R737[医药卫生—肿瘤]