大肠癌术后腹腔及静脉化疗对细胞免疫的影响  

THE INFLUENCE OF INTRAVENOUS AND INTRAPERITONEAL CHEMOTHERAPY ON CELL-MEDIATED IMMUNITY AFTER COLORECTAL CANCER SURGERY

作　　者：李力波[1] 卞家兴[1] 杨力军[1] 

机构地区：[1]广州铁路中心医院普外二区

出　　处：《中国现代医学杂志》1999年第2期8-9,共2页China Journal of Modern Medicine

摘　　要：为观察静脉化疗及腹腔化疗对细胞免疫的影响，选择较好的化疗方案，自１９９４年起，连续对１８例大肠癌根治术后早期静脉化疗及２１例腹腔化疗病人进行观察，行５－Ｆｕ加左旋咪唑方案化疗。通过化疗前后抽血检查Ｔ细胞亚群比例及ＮＫ细胞比例的变化，发现腹腔化疗组上述指标无明显下降，静脉化疗组下降明显，证明腹腔化疗对细胞免疫抑制较重。The effects of intraperitoneal chemotherapy on cell-mediated immunity were compared and the more effective method was identified.Eighteen patients were treated with intravenous chemotherapy and 21 patients were treated with intraperitoneal chemotherapy.5-Fu and Levamisole were administered.The ratio of subgroup T cells and NK cells was determined using haemospasia before and after chemotherapy.It was discovered that the ratio declined less in the intraperitoneal cases than in the intravenous cases.This indicates that cell-mediated immunity is depressed to a lesser degree after intraperitoneal chemotherapy.Intraperitoneal chemotherapy is a more effective adjuvant treatment for postoperative colorectal cancer patients.

关 键 词：大肠癌 腹腔化疗 静脉化疗 细胞免疫 

分 类 号：R735.340.5[医药卫生—肿瘤]