趋化因子受体CXCR4及其配体SDF-1在胃癌中的表达与临床病理因素的关系  

THE RELATIONSHIP OF EXPRESSION OF CXCR4 AND ITS LIGAND SDF-1 IN GASTRIC CANCER AND SEVERAL CLINICOPATHOLOGICAL FACTORS

作　　者：陆航[1] 刘学政[2] 

机构地区：[1]辽宁医学院附属第一医院普外科,锦州121001 [2]辽宁医学院解剖学教研室

出　　处：《现代预防医学》2010年第11期2155-2158,共4页Modern Preventive Medicine

摘　　要：[目的]观察趋化因子受体CXCR4及其配体SDF-1在胃癌中的表达情况及其与胃癌临床病理特征的关系。[方法]辽宁医学院附属第一医院行胃切除术的62例胃癌患者的手术切除标本中CXCR4和SDF-1的表达水平采用免疫组化检测。观察CXCR4和SDF-1蛋白在胃癌细胞内的免疫染色情况。[结果]肠型胃癌细胞CXCR4和SDF-1的染色强度明显高于弥漫型胃癌。在肠型胃癌中CXCR4和SDF-1的表达与肝转移和淋巴结转移显著相关,但弥漫型胃癌无此相关性。[结论]CXCR4和SDF-1在肠型胃癌细胞的高表达可能成为阻止淋巴和血行转移治疗的靶点。[Objective] To explore the relationship between the expression of CXCR4 and its ligand SDF-1 in gastric cancer and several clinicopathological factors. [Methods] The specimens were surgically resected from 62 patients with gastric cancer who underwent gastrectomy in The First Affiliated Hospital of Liaoning Medical College. CXCR4 and SDF-1 expression levels in gastric cancer specimens obtained from 62 patients were examined by immunohistochemistry. [Results] The staining intensity of CXCR4 and SDF-1 in cancer cells was significantly higher in intestinal-type than in diffuse-type gastric cancer. There was a significant correlation between the expression of CXCR4 and SDF-1 and liver metastasis and lymphatic metastasis in the intestinal-type cancer; however, this correlation was not found in the diffuse-type cancer. Furthermore, intestinal-type cancer cells that permeated the vascular or lymphatic channels as well as liver and lymph node metastases showed strong CXCR4 and SDF-1 staining. [Conclusion] The over-expressed CXCR4 and SDF-1 in intestinal-type cancer cells may be therapeutic targets for preventing lymphatic and hematogenous metastasis.

关 键 词：CXCR4 SDF-1 胃癌 转移 免疫组织化学 

分 类 号：R735.2[医药卫生—肿瘤]