基质金属蛋白酶-9及高敏C反应蛋白测定对恶性大脑中动脉梗死的预测意义  

Prediction of malignant middle cerebral artery infarction by plasma MMP-9 and hsCRP level

作　　者：巫顺秀[1] 李雯[1] 张凌玲[1] 庄伟端[1] 郑璇[1] 肖颖秀[1] 陈荣波[1] 

机构地区：[1]汕头大学医学院第一附属医院神经内科,广东省汕头515041

出　　处：《中国基层医药》2010年第10期1303-1305,共3页Chinese Journal of Primary Medicine and Pharmacy

基　　金：广东省汕头市科委科研课题（2009-70）

摘　　要：目的 探讨内皮损伤标志物基质金属蛋白酶-9（MMP-9）及血清高敏C反应蛋白（hsCRP）在急性大脑前循环区脑梗死临床进展为恶性大脑中动脉梗死（m-MCAI）的作用机制.方法 收集大脑前循环区脑梗死患者90例,其中46例进展为m-MCAI.在患者入院时,以ELISA和免疫比浊法检测患者血浆MMP-9和hsCRP,并结合患者NIHSS评分及早期头颅CT改变进行分析.结果 入院时,m-MCAI患者血浆MMP-9（242.0±58.0）ng/ml明显高于非m-MCAI患者（169.0±50.0）ng/ml（P〈0.01）,m-MCA患音血浆hsCRP（6.25±1.2）mg/ml明显高于非m-MCAI患者（1.55±0.9）mg/ml（P〈0.01）.结论 早期头颅CT检查结果及血浆MMP-9、hsCRP水平增高对预测m-MCAI进程有一定意义.Objective To evaluate the predicting value of the marker of endothelial injury： plasma matrix metalloproteinase-9（ MMP-9） and high sensitivity C-reactive protein（ hsCRP） level on the progression of acute anterior circulating territory infarction progressing to malignant middle cerebral artery infarction （m-MCAI）. Methods 90 patients with acute anterior circulating territory infarction, in which 46 patients progressed to m-MCAI, were collected and sampled consecutively. The plasma MMP-9 and hsCRP of all patients were determined by ELISA and immunotur-bidimetry,respectively,at admission. And the clinical characters and cranial CT features of the patients were analyzed. Results At admission,the plasma MMP-9 level in the patients with m-MCAI（242.0 ±58.0）ng/ml was significantly higher than that in the patients with non m-MCAI（ 169.0 ± 50.0） ng/ml（ P 〈 0. 01） ,the plasma hsCRP level in the patients with m-MCAI（6.25 ±1.2） ng/ml was significantly higher than that in the patients with non m-MCAI（ 1.55 ± 0.9） mg/ml（ P 〈0. 01）.Conclusion The increased level of plasma MMP-9 and hsCRP could be predictors for the m-MCAI proceeding.

关 键 词：梗塞 大脑中动脉 基质金属蛋白酶9 C反应蛋白质 体层摄影术 X线计算机 

分 类 号：R74[医药卫生—神经病学与精神病学] R73[医药卫生—临床医学]