乳腺癌中过氧化物酶体增殖激活受体γ和β-连环蛋白表达及临床意义  

Expression and clinical significance of FPARγ and β-catenin in breast cancer

作　　者：江颖[1,2] 邹琳[3] 张春晖[2] 陆维祺[1] 朱隽[1] 罗文杰[1] 张华[1] 沈爱国[3] 

机构地区：[1]复旦大学附属中山医院普外科,上海200032 [2]南通大学附属医院普外科 [3]南通大学

出　　处：《中华实验外科杂志》2010年第6期699-701,共3页Chinese Journal of Experimental Surgery

基　　金：国家自然科学基金资助项目（30972937）;教育部高等学校博士点专项基金资助项目（20070246131）;江苏省自然科学基金资助项目（BK2006546）;江苏省六大人才高峰资助项目（06-B-065）;南通大学博士启动基金资助项目（03080174）

摘　　要：目的 探讨过氧化物酶体增殖激活受体γ（PPARγ）和β-连环蛋白（β-catenin）在乳腺癌组织中的表达、相关性及与乳腺癌临床和预后的关系.方法 采用免疫组织化学法检测70例乳腺癌组织和20例乳腺良性肿瘤中PPARγ和β-catenin的表达,并进行临床分析.结果 乳腺癌PPARγ高表达率为34.3%（24/70）,明显低于乳腺良性肿瘤;β-catenin在乳腺癌中异常表达率为67.1%（47/70）,PPARγ和β-catenin蛋白表达呈显著负相关（r=-0.398,P〈0.05）.PPARγ蛋白表达水平与乳腺癌组织学分级、TNM分期、淋巴结转移、肿瘤大小及Ki-67表达负相关（P〈0.05）,与雌激素受体（ER）状态及总体生存率正相关（P〈0.05）;β-catenin蛋白异常表达与乳腺癌组织学分级、TNM分期、淋巴结转移正相关（P〈0.05）,与总体生存率负相关（P〈0.05）.结论 PPARγ和β-catenin表达与乳腺癌发展有关,检测PPARγ和β-catenin表达对判断乳腺癌生物学行为和预后具有参考价值.Objective To study the expression of peroxisome proliferator-activated receptor γ （PPARγ） and β-catenin in breast cancer, and their correlations with clinicopathological parameters and prognosis. Methods Tissue samples obtained from 70 patients with breast cancer and 20 patients with breast benign mass were immunohistochemically examined for the expression of PPARγ and p-catenin. Results Overexpression rate of PPARγ protein was 34. 3% in breast cancer, significantly lower than that in breast benign mass. Abnormal expression rate of β-catenin in breast cancer was 67. 1%. A significant negative-correlation was found between the expression of PPARγ and β-catenin （r=-0. 398,P〈0.05 ）. PPARγ expression was inversely associated with histologic grade, tumor size, axillary lymph node metastasis,TNM stage and Ki-67 expression （P〈0. 05）, while positively correlated with ER status and overall survival rate （P〈0. 05）. Abnormal β-catenin expression was positively associated with histologic grade, axillary lymph node metastasis and TNM stage （P〈0. 05）, while inversely correlated with overall survival rate （P〈0.05）. Conclusion PPARγ and β-catenin are correlated with development of breast carcinoma,suggesting that detection of PPARγ and β-catenin may be of value in evaluating the biological behaviors and the prognosis of breast cancer.

关 键 词：乳腺肿瘤 过氧化物酶体增殖激活受体Γ Β-连环蛋白 预后 

分 类 号：R737.9[医药卫生—肿瘤]