Wernicke脑病临床和影像学分析  

作　　者：周亮[1] 刘学政[1] 

机构地区：[1]江西井冈山大学医学院临床系,343600

出　　处：《医学信息（下旬刊）》2010年第4期48-49,共2页Medical information

摘　　要：目的：探讨韦尼克脑病（WE）的病因、临床表现和影像学特征，提高WE的临床早期诊断率。方法：对4例WE病例的临床特点、MRI影像特征及治疗转归等诊断过程进行回顾性分析总结。结果：4例患者中，2例为手术后，1例为急性胰腺炎，1例为妊娠剧吐，均因进食不足、吸收不良和代谢障碍导致硫胺摄入不足。4例在MRJ影像学上均表现出在丘脑内侧、脑桥被盖部、中脑导水管及脑室周围等有对称性损害，12WI上呈高信号，FLAIR序列及DWI呈明显高信号，具有特异性。4例患者经给予维生素B1治疗后，病情都呈戏剧性改善。例4患者在治疗一个月后复查头颅MRI检查，原有病灶均已消失。结论：WE是少数具有特异性治疗方法的神经系统急危重症之一，早期诊断和早期治疗对WE的预后有重要的意义。头颅MRJ对早期诊断有重要价值。objective To investigate etiopathogenisis, clinical manifestation and MRI features of wernicke encephalopathy（WE） , and raise the rate of early confirmed diagnosis. Methods We analyzed retrospectivel y the clinical characters, MR1 features, and outcomes material in 4 cases of WE. Result In 4 cases of WE,two cases were postop,one was acute pancreatitis and the last one was hyperemesis gravidarum. They were devoid of thiamine for underfeed, malabsorption and dysbolism. 4 cases showed symmetrical lesions in the medial thalamus, tegmentum of pons, the surrounding of the aqueduct and ventricle in cranial MRI. The patients exhibited areas of increased T2W signal and obviously increased flair and diffusion weighted signal. They were administed vitamin B1 and the symptoms improved dramatically. One case in MRI signals showed to resolve after therapy for one month. Conclusions WE who was one of nervous system severe cases can be specially treated. Early diagnosis and therapy has a important significance for the prognosis of WE. MRI has great diagnostic value for early diagnosis.

关 键 词：WERNICKE脑病 临床 磁共振成像 

分 类 号：R742[医药卫生—神经病学与精神病学]