兔VX2肝移植瘤磁共振背景信号抑制弥散加权成像的实验研究  

Experimental Research of Magnetic Resonance Diffusion Weighted Imaging with Background Suppression in Rabbit VX2 Hepatic Implantation Tumor

作　　者：葛艳明[1] 李耀武[1] 王滨[1] 董鹏[1] 戴生[1] 周永红[1] 

机构地区：[1]潍坊医学院附属医院影像中心潍坊医学院医学影像学系,山东潍坊261031

出　　处：《实用放射学杂志》2010年第5期732-735,共4页Journal of Practical Radiology

基　　金：山东省科技发展计划项目（2007GG30002032）、山东省卫生系统杰出学科带头人基金（2006-39）、山东省教育厅重点项目（J04E01）.

摘　　要：目的 探讨磁共振背景信号抑制弥散加权体部成像在经肝动脉化疗栓塞术联合静脉注射血管生成抑制剂内皮抑素治疗VX2肝移植瘤疗效评价中的作用.方法 荷瘤兔随机分为2组,每组8只.对照组经耳缘静脉注射生理盐水10 ml/d,连续应用12 d;介入治疗（TACE＋ES）组经肝动脉给予超液化碘油0.2 ml/kg和阿霉素2 mg/kg,并经耳缘静脉注射内皮抑素0.7 mg/kg·d,连续应用12 d.2组均于治疗前后行MR DWIBS检查,分别测量各组肿瘤组织在不同时间点的表观弥散系数,并评价DWIBS及DWIBS原始图经3D MIP重建及黑白翻转获得类PET图像的图像特征.结果 ADC值从治疗后第3天起即有变化,TACE＋ES组ADC值在治疗后第3、7、13天均高于对照组并有统计学意义（P〈0.05）.结论 DWIBS结合ADC值的定量测量可为VX2肝肿瘤的诊断、分期、疗效评价提供有价值的信息.Objective To discuss the value of MR diffusion weighted imaging with background suppression（DWIBS） in assessing the anti--tumor therapeutic response on VX2 hepatic tumors. Methods 16 rabbits with VX2 hepatic tumors were randomly divided into two groups（eight rabbits in each group）. For control group, normal saline （10ml/d） were administered via the ear vein for each rabbit, and the duration of the treatment lasted 12 days; For interventiona! therapy（TACE＋ES） group, lipiodol （0.2 ml/kg） and ADM （2 mg/kg） were administered via the hepatic artery and endostatin （0.7 mg/kg · d） was administered via the ear vein injection for every rabbit. DWIBS were performed in all subjects prior and after treatment. Apparent diffusion coefficient （ADC） values of the tumors were evaluated in all cases. MRI appearances on DWIBS and similar PET images （DWIBS primary images with 3D MIP reconstruction and black--white inersion） were compared. Results ADC values showed dramatical change from 3 days after treatment. ADC values in TACE＋ES group was higher than that in control group and there was statistical difference among them at each time point （P〈0.05）. Conclusion DWIBS Combining with ADC value can assess the anti-tumor therapeutic response atraumatically on living body,and will be helpful for diagnosis,staging and curative effect evaluation of VX2 tumors.

关 键 词：VX2 肝移植瘤 化学栓塞 磁共振成像 实验研究 

分 类 号：R-322[医药卫生] R735.7