凋亡抑制蛋白Livin在胃癌及癌旁组织中的表达  被引量:16

Expression of inhibitor of apoptosis protein Livin in gastric cancer and adjacent non-cancerous tissue

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作  者:侯毅鞠[1] 李艳[1] 袁忠海[1] 郭素红[1] 

机构地区:[1]吉林医药学院临床检验系,吉林省吉林市132013

出  处:《世界华人消化杂志》2010年第12期1196-1200,共5页World Chinese Journal of Digestology

基  金:吉林省教育厅"十一五"基金资助项目;No.2008405~~

摘  要:目的:分析Livin蛋白在胃癌及癌旁组织中的表达,并根据其与胃癌生物学行为之间的关系分析对胃癌预后评估的意义.方法:采用免疫组织化学SP法检测50例胃癌及癌旁组织中Livin蛋白,以Image-ProPlus6.0专业图像分析软件定量分析其表达.并通过比较不同类型组织切片中表达量的差异,分析其在胃癌中表达的意义.结果:Livin蛋白在胃癌组织中表达显著高于癌旁组织(IA:283270.55±199604.16vs6878.08±9214.56,P<0.01).不同类型癌组织中表达亦有显著差异,高-中分化癌组织明显低于低-未分化(41288.94±27891.09vs359690.5±166583.17,P<0.01);浸润未达浆膜层(T1-2)者显著低于达浆膜层(T3-4)者(85529.62±115287.42vs360174.77±170507.09,P<0.01);伴淋巴转移者显著高于无淋巴转移(380949.72±171073.92vs148547.51±152479.47,P<0.01).结论:Livin蛋白高表达于胃癌组织,在不同分化程度、浸润度以及有无淋巴转移组间的表达都有显著差异.Livin蛋白高度表达预示肿瘤有较高的侵袭性,可用于判断胃癌预后.AIM:To detect the expression of Livin protein in gastric cancer and adjacent non-cancerous tissue,and to analyze its prognostic significance by exploring the relationship between Livin expression and the biological behavior of gastric cancer.METHODS:The expression of Livin was detected by immunohistochemistry (streptavidinperoxidase method) in 50 gastric cancer and matched adjacent non-cancerous tissue samples.Quantitative analysis of Livin expression was performed with the Image-Pro Plus 6.0 software.The significance of Livin expression in gastric cancer was then analyzed.RESULTS:The integrated absorbance (IA) value of Livin staining in gastric cancer tissue was significantly higher than that in adjacent non-cancerous tissue (283 270.55 ± 199 604.16 vs 6 878.08 ± 9 214.56,P 〈0.01).The IA value was lower in well and moderately differentiated cancer tissue than in poorly and undifferentiated tissue (41 288.94 ± 27 891.09 vs 359 690.5 ± 166 583.17,P M0.01),in cancer tissue not invading the serosal layer than in that invading the serosal layer (T3-4) (85 529.62 ± 115 287.42 vs 360 174.77 ± 170 507.09,P〈 0.01),and in gastric cancer without lymph node metastasis than in that with lymph node metastasis (148 547.51 ± 152 479.47 vs 380 949.72 ± 171 073.92,P〈 0.01).CONCLUSION:Livin protein is highly expressed in gastric cancer.Livin expression is significantly associated with tumor differentiation,infiltration and lymph node metastasis in gastric caner.Livin protein may be used as a prognostic marker for gastric cancer.

关 键 词:胃癌 LIVIN 诊断 预后 

分 类 号:R735.2[医药卫生—肿瘤]

 

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