CDH1 C-160A基因多态性与胃癌易感性的Meta分析  

CDH1 C-160A promoter polymorphism and genetic susceptibility to gastric cancer:a meta-analysis

作　　者：曹伟军[1] 张振玉[1] 岳巧艳[1] 

机构地区：[1]南京医科大学附属南京第一医院消化内科,江苏省南京市210006

出　　处：《世界华人消化杂志》2010年第12期1270-1274,共5页World Chinese Journal of Digestology

摘　　要：目的:探讨CDH1C-160A基因多态性与胃癌易感性的关系.方法:检索中国生物医学文献数据库、万方数据库、中国期刊网和PubMed,获取CDH1C-160A基因多态性与胃癌易感性的病例-对照研究.以胃癌组与对照组人群基因型分布的OR值为效应指标,采用固定或随机效应模型进行合并分析,并进行偏倚评估.应用STATA10.0软件进行统计学处理.结果:共纳入文献13篇,研究14项,累计胃癌病例3144例,对照4221例.与野生基因型CC相比,(CA+AA)合并的OR值(95%CI)为0.98(0.84-1.15).按人群进行分层分析,亚洲人群OR值为0.92(0.81-1.04),高加索人群OR值为1.21(0.88-1.67).结论:CDH1C-160A基因多态性与胃癌易感性无关.AIM：To investigate the relationship between E-cadherin （CDH1） gene C-160A promoter polymorphism and genetic susceptibility to gastric cancer.METHODS：Chinese biomedicine disc （CBM）,Wanfang database,China National Knowledge Infrastructure （CNKI） and PubMed were searched for published case-control studies investigating the association between CDH1 C-160A promoter polymorphism and susceptibility to gastric cancer.The odds ratio was calculated to evaluate the genotypes of gastric cancer patients and control subjects.Fixed or random effect models were selected for pooled odds ratio calculation.Publication bias was assessed.All statistical analyses were conducted with Stata 10.0 software.RESULTS：A total of 14 case-control studies involving 3 144 gastric cancer patients and 4 221 controls were analyzed in the study.Compared with the wild-type genotype （homozygote CC）,the pooled odds ratio [and 95% confidence interval （CI）] for CA and AA genotypes was 0.98 （0.84-1.15）.In the population subgroup analysis,the odds ratios for Asian and Caucasian populations were 0.92 （0.81-1.04） and 1.21 （0.88-1.67）,respectively.CONCLUSION：CDH1 C-160A promoter polymorphism is not associated with genetic susceptibility to gastric cancer.

关 键 词：CDH1 胃癌 基因多态性 META分析 

分 类 号：R735.2[医药卫生—肿瘤]