ps电场脉冲无创治疗肿瘤的方法及天线设计  

Non-invasive Treatment of Tumors by Using Picosecond Electric Pulse and Antenna Design

作　　者：龙再全[1] 姚陈果[1] 孙才新[1] 李成祥[1] 米彦[1] 

机构地区：[1]重庆大学输配电装备及系统安全与新技术国家重点实验室,重庆400030

出　　处：《高电压技术》2010年第5期1275-1280,共6页High Voltage Engineering

基　　金：国家自然科学基金(50637020;50877083)~~

摘　　要：由于细胞线粒体膜的充电时间常数远小于细胞核膜与细胞膜的充电时间常数,在ps电场脉冲作用下,线粒体膜将先于细胞核膜与细胞膜受到脉冲的影响。为此,整合无创治疗的应用需求以及电场脉冲靶向诱导肿瘤细胞凋亡的窗口效应,提出通过冲激脉冲辐射天线将ps脉冲聚焦于肿瘤组织,使肿瘤细胞线粒体跨膜电位发生变化而崩溃,启动线粒体途径的凋亡靶向诱导,实现肿瘤的无创治疗,初步实验与仿真结果表明该理论的可行性。根据超宽带天线设计理论,设计了一种用于辐射ps电场脉冲的冲激脉冲辐射聚焦天线,初步优化结果显示当金属板与x轴夹角β为90°~95°以及单圆锥辐射器的半张角α为30°~35°时,可以使天线在靶点位置得到最大的场强分布。Considering the application of non-invasive treatment and window effects of cell apoptosis targeted induced by electric pulses,method of non-invasive treatment of tumors was proposed.With picosecond pulse focusing on the tumor tissue by using impulse radiating antenna（IRA）,the mitochondrial transmembrane would change to collapse under which the tumor cells could be targeted induced to apoptosis in mitochondrial pathway.Preliminary experimental and simulation results show that the theory is correct.On the basis of the theory of ultra-wide-band antenna,we designed an impulse radiating antenna by which picosecond pulse could be radiated and some preliminary optimizations of the antenna were made.While β was 90°~95°and α was 30°~35°,the maximum E-field distribution could be achieved.

关 键 词：ps脉冲 线粒体膜 冲激脉冲辐射天线 凋亡 无创治疗 超宽带 

分 类 号：R730.5[医药卫生—肿瘤]