Id-1在恶性肿瘤发生中的作用及其机制  

The roles and mechanisms of Id-1 in tumorigenesis

作　　者：郭斌[1] 张成梅[2] 刘少华[1] 

机构地区：[1]山东大学齐鲁医院口腔颌面外科,济南250012 [2]山东大学动物实验中心,济南250012

出　　处：《生命科学》2010年第5期401-404,共4页Chinese Bulletin of Life Sciences

基　　金：国家自然科学基金项目(30672339)

摘　　要：分化抑制因子-1(inhibitor of differentiation protein 1,Id-1)是Id转录调节蛋白家族成员之一,属于螺旋-环-螺旋蛋白超家族成员。早期对Id-1的研究认为其主要作用是负向调节正常细胞的分化。近年来研究表明,Id-1在多种肿瘤中过表达并通过多条信号通路促进肿瘤的发生,现就Id-1在肿瘤发生中的作用及其作用机制作一综述。Id-1 （inhibitor of differentiation protein 1） is a member of Id protein family, belongs to the helix-loop-helix proteins superfamily. Early studies have shown that Id-1 mainly acted as a negative regulator of cell differetiation. Recently, Id-1 overexpression has been found in plenty of cancers by promoting tumorigenesis through several signal pathways. This review will focus on the roles of Id-1 in tumorigenesis and its relative mechanisms.

关 键 词：分化抑制因子-1 肿瘤发生 机制 

分 类 号：Q254[生物学—细胞生物学] R730.1[医药卫生—肿瘤]