利什曼原虫胞内寄生相关基因的研究  

The research on genes related to the endoparasitic Leishmania

作　　者：曹得萍[1] 陈建平[1] 

机构地区：[1]四川大学基础医学与法医学院寄生虫学教研室,成都610041

出　　处：《国际医学寄生虫病杂志》2010年第3期172-176,共5页International JOurnal of Medical Parasitic Diseases

基　　金：国家十一五重大科技专项（2008ZX10004-011）;国家自然科学基金（30771883）

摘　　要：利什曼病是由利什曼原虫无鞭毛体寄生在包括人在内的哺乳动物巨噬细胞而引起的疾病,由杜氏利什曼原虫引起的内脏利什曼病若不治疗则会致命.研究者对寄生在白蛉属消化道内的前鞭毛体和寄生在巨噬细胞内的无鞭毛体胞内高表达基因或蛋白进行研究,筛选出一些特异基因,为利什曼原虫疫苗候选抗原的确定和靶作用药物的确定提供了科学依据.Leishmaniasis is a disease caused by Leishmania spp. amastigotes which parasitize in the macrophage cells of mammals including human being. Visceral leishmaniasis caused by Leishmania donovani is usually fatal if not properly treated. Parasitological studies have found some special genes by screening high expressed genes or proteins in motile promastigotes existing in the midgut of sandflies and non-motile amastigotes residing in macrophages. These findings may provide a scientific foundation to determine target drugs and candidate antigens of Leishmania vaccine.

关 键 词：利什曼原虫 前鞭毛体 无鞭毛体 毒力基因 胞内基因 

分 类 号：R382.22[医药卫生—医学寄生虫学]