紫杉醇治疗小鼠S180肉瘤的体内^(31)P MRS研究  

IN VIVO STUDIES OF TAXOL CHEMOTHERAPY IN A MOUSE S180 SARCOMA BY 31 P MAGNETIC RESONANCE SPECTROSCOPY

作　　者：田建广[1,2] 魏昌华[1,2] 冯锐[1,2] 李光玉[1,2] 茹祥斌 杜泽涵 

机构地区：[1]军事医学科学院国家生物医学分析中心 [2]军事医学科学院毒物药物研究所

出　　处：《波谱学杂志》1999年第1期5-10,共6页Chinese Journal of Magnetic Resonance

摘　　要：为了研究紫杉醇治疗小鼠Ｓ１８０肉瘤的３１ＰＭＲＳ参数的变化及这些参数的变化是否早于常规观察的瘤体积的变化．方法：利用表面线圈３１ＰＮＭＲ方法，研究小鼠皮下接种的Ｓ１８０肉瘤．结果：用药４８ｈ后给药组的ＰＣｒ／Ｐｉ、βＮＴＰ／Ｐｉ、ＰＭＥ／βＮＴＰ比值与对照组有显著性差别（Ｐ＜０．０５），而肿瘤体积在给药组和对照组之间无显著性差别，３１ＰＭＲＳ参数的变化早于瘤体积变化．结论：小鼠Ｓ１８０肉瘤３１ＰＭＲＳ不仅可以给出定量的结果，而且可以较早地显示出治疗的效果．Objective: To study whether the changes of 31 P MRS parameters of mouse S180 sarcoma treated by Taxol is earlier than the changes of tumor volume. Methods: Mouse S180 sarcoma (i.p.) was studied by using surface-coil 31 P NMR. Results:After 48h following treatment, PCr/Pi and β NTP/Pi ratios of treated groups are higher than those of control group ( P <0.05), PME/β NTP ratio of treated groups is lower than that of control group ( P <0.05). The tumor volume between treated groups and control group showed no significant difference. Conclusion: 31 P MRS of mouse S180 sarcoma can offer not only quantitative information, but show also earlier response to therapy.

关 键 词：紫杉醇 小鼠S180肉瘤 MRS 磷31 化疗 

分 类 号：R730.53[医药卫生—肿瘤]