奥美拉唑与雷尼替丁治疗消化性溃疡临床对比观察  

The Clinical Observation of Comparing Omeprazole with Ranitidine in Treatment of Peptic Ulcer

作　　者：刘绍田[1] 

机构地区：[1]崇州市人民医院,四川成都611230

出　　处：《现代临床医学》2010年第3期184-185,共2页Journal of Modern Clinical Medicine

摘　　要：目的:观察两种不同的方案治疗消化性溃疡的临床疗效,探讨治疗消化性溃疡的有效方法。方法:对照组幽门螺杆菌(HP)阳性者给予1周的HP根除治疗,之后给予奥美拉唑肠溶片,连续4周,HP阴性者直接给予奥美拉唑肠溶片20 mg,q d,连续5周。治疗组HP阳性者给予对照组相同的HP根除治疗方案,1周后给予雷尼替丁,连续用药4周,HP阴性者直接给予雷尼替丁,连续用药5周。所有患者在治疗后1周复诊1次,记录腹痛、反酸、上腹烧灼感消化道症状改善情况,并于5周疗程结束时复查胃镜情况。结果:治疗组临床治愈率达到83.33%,明显优越于对照组的57.69%(P<0.05),总有效率方面治疗组全部有效,明显优越于对照组的76.92%(P<0.05)。胃镜下治疗组临床痊愈、总有效率分别为76.67%、96.67%,与对照组的50%、69.23%相比均有明显差异(P<0.05)。结论:质子泵抑酸剂奥美拉唑在消化性溃疡优越于H2受体拮抗剂雷尼替丁的治疗作用,是临床上值得推广的治疗消化性溃疡的首选药物。Objective：To observe two different clinical efficacy in the treatment of peptic ulcer and to explore effective means of treatment of peptic ulcer.Methods：HP-positive control group had 1 week of HP eradication therapy,then took omeprazole enteric-coated tablets for 4w;HP-negative took a direct omeprazole enteric-coated tablets 20 mg·d-1 times for 5w.Treatment group： HP-positive control group had the same HP eradication therapy program 1 week,then took ranitidine medication for 4w,HP-negative directly took ranitidine medication for 5w.All the patients returnned visit after 1 week treatment,referral time,recorded abdominal pain、acid reflux、epigastric burning sensation、 gastrointestinal symptoms improveed,and in the end of 5 weeks treatment,had the endoscopy examination.Results：In the treatment group clinical cure rate was 83.33%,significantly superior to control group 57.69%（P0.05）,the total efficiency of the treatment groups,significantly superior to control groups 76.92%（P0.05）.Under endoscopic,in treatment group the recovery and total effective rates were 76.67%,96.67%,and in control group was 50%,69.23%.The two groups were significantly different（P0.05）.Conclusion：Proton pump antisecretory agent omeprazole in treatment of peptic ulcer is superior to H2 receptor antagonist ranitidine and should be first choice.

关 键 词：消化性溃疡 奥美拉唑 幽门螺杆菌 

分 类 号：R573[医药卫生—消化系统]