壮族人群少精不育患者精细胞GSTT1和GSTM1基因研究  

The research on GSTT1 and GSTM1 gene polymorphisms of the patients with oligospermous infertility of Zhuang population in Guangxi area

作　　者：陈文成[1] 康熙雄[2] 韦叶生[1] 潘云[1] 周亚莉[2] 张国军[2] 

机构地区：[1]右江民族医学院医学检验学院,百色533000 [2]首都医科大学附属北京天坛医院检验科,北京100050

出　　处：《中国免疫学杂志》2010年第5期425-427,共3页Chinese Journal of Immunology

基　　金：国家高技术研究发展计划(863计划)-<免疫诊断试剂>子课题(生物医学关键试剂;2006AA020908);广西教育厅基金(200810LX376)资助

摘　　要：目的:探讨壮族人群精细胞GSTT1和GSTM1基因多态性与少精症的关系。方法:应用PCR法对75名壮族少精不育患者及36名健康男性精细胞GSTT1和GSTM1基因进行多态性研究,探讨该基因对少精症的影响。结果:实验组GSTM1基因及GSTM1+GSTT1组合的缺失型基因高于对照组,差异有统计学意义(P<0.05)。结论:壮族人群精细胞GSTM1基因和GSTT1+GSTM1基因多态性与男性少精症有着较为密切的联系,其具体作用机制有待进一步研究。Objective：To explore the association of the genes GSTM1 and GSTT1 with oligozoospermia infertility.Methods：PCR technique was used to analyze the GSTM1 and GSTT1 genes polymorphisms in 75 with oligospermia infertility and 36 healthy individuals of Zhuang population from Guangxi Baise area,and then the possibility function of GSTM1 and GSTT1 genes in human oligozoospermia were studied.Results：Analyses of the polymorphisms in GSTM1 and GSTT1 genes showed that GSTM1 defect or combined defects of both GSTM1 and GSTT1 was found more frequent in patients with infertile oligospermia than in the healthy control.Conclusion：GSTM1 and GSTT1 genes may have modulating effects on human spermatogenesis,whose mechanism needs further studies.

关 键 词：GSTT1 GSTM1 少精症 不育症 

分 类 号：R734.202[医药卫生—肿瘤]