八味沉香散水提液对垂体后叶素致大鼠急性心肌缺血的保护作用  

Protective effect of liquid-extract of Bawei Chenxiang powder on myocardial ischemia induced by pituitrin in rats

作　　者：李永芳[1] 寇毅英[1] 杨梅[1] 马祁生[1] 格日力[1] 

机构地区：[1]青海大学医学院,青海西宁810001

出　　处：《华西药学杂志》2010年第3期300-302,共3页West China Journal of Pharmaceutical Sciences

基　　金：青海省科技厅资助项目(项目编号:2005-J-801)

摘　　要：目的评价八味沉香散水提液(LEBCP)对垂体后叶素诱发大鼠急性心肌缺血的保护作用。方法采用大鼠舌下静脉注射垂体后叶素制备急性心肌缺血模型,观察LEBCP对大鼠注射垂体后叶素后血流动力学和心肌超微结构的影响。结果 LEBCP能明显改善垂体后叶素引起的心脏舒缩功能下降,并能减轻心肌超微结构的损伤。结论 LEBCP对垂体后叶素所致大鼠急性心肌缺血具有一定的保护作用。OBJECTIVE To evaluate the cardioprotective effect of liquid-extract of Bawei Chenxiang powder（LEBCP） in rats with myocardial injury induced by pituitrin.METHODS A myocardial ischemia model of rats was established by intravenous injection with pituitrin.The LVSP,± dp/dtmax and LVEDP were measured and the myocardia were examined with electron microscope.RESULTS The LEBCP could improve the function of systole and diastole,and histological changes of hearts with pituitrin-induced myocardial ischemia.CONCLUSION The LEBCP has the protective effect against pituitrin-induced myocardial injury in rats.

关 键 词：八味沉香散水提液 急性心肌缺血 垂体后叶素 

分 类 号：R285[医药卫生—中药学]