单相抑郁症中5-HT2A受体基因及MAOA型基因的相互影响  

An interaction between 5-HT 2A receptor gene and MAOA gene in unipolar depressive patients.

作　　者：江开达[1,2,3] 江三多[1,2,3] 王红霞 杨晓敏[1,2,3] 王慧芳 林嗣萃 钱伊萍[1,2,3] 

机构地区：[1]上海医科大学精神医学教研室 [2]上海精神卫生中心 [3]湖北沙市精神病院

出　　处：《中国神经精神疾病杂志》1999年第2期90-92,共3页Chinese Journal of Nervous and Mental Diseases

摘　　要：目的探讨单相抑郁症病因中５－ＨＴ２Ａ受体基因与ＭＡＯＡ型基因的相互影响。方法在７２例单相抑郁症患者和８１例正常健康人中，采用ＰＣＲ－ＲＦＬＰ和Ａｍｐ－ＦＬＰ技术检测５－ＨＴ２Ａ和ＭＡＯＡ型的等位基因和基因型分布。结果单相抑郁症与５－ＨＴ２Ａ基因间无遗传关联，但是具５－ＨＴ２Ａ的Ａ２／Ａ２基因型患者与ＭＡＯＡ型的１１４ｂｐ等位基因呈强烈关联（ＲＲ＝６．２５，Ｐ＜００５）。结论５－ＨＴ２Ａ受体基因和ＭＡＯＡ型基因在单相抑郁症发生中可能起有一定相互作用。Objective To investigate the interaction between 5-HT 2A receptor gene and MAOA gene in unipolar depressive patients. Methods The alleles and genotypes of 5-HT 2A receptor gene and MAOA gene were examined with PCR-RFLP and Amp-FLP techniques in 72 unipolar depressive patients and 81 healthy controls. Results There was no correlation between unipolar depression and 5-HT 2A receptor gene,but the 114bp allele of MAOA gene had a significant correlation with the unipolar depressive patients with A2/A2 genotype of 5-HT 2A receptor gene ( RR=6.25,P <0.05). Conclusions An interaction between 5-HT 2A receptor gene and MAOA gene may exist in the etiology of unipolar depression.

关 键 词：单相抑郁症 5-HT2A受体基因 MAOA型基因 抑郁症 

分 类 号：R749.4[医药卫生—神经病学与精神病学]