抚顺、盘锦两市城乡宫颈癌及宫颈上皮内瘤变的现患率调查及危险因素分析  

Risk Factors and Prevalence of Cervical Intraepithelial Neoplasia and Cervical Cancer in Fushun and Panjin City,Liaoning Province

作　　者：王纯雁[1] 姚文庆[1] 张淑兰[2] 张新[1] 高岩[1] 汤巍巍[1] 王晓彬[1] 龙再秋[1] 李雪梅[1] 王蕾[1] 李联崑[1] 

机构地区：[1]辽宁省肿瘤医院,辽宁沈阳110042 [2]中国医科大学附属盛京医院,辽宁沈阳110004

出　　处：《中国肿瘤》2010年第6期367-371,共5页China Cancer

基　　金：辽宁省卫生厅临床医学重点专科建设项目

摘　　要：[目的]探讨辽宁省抚顺、盘锦两市城乡宫颈癌及宫颈上皮内瘤变（CIN）的现患率,并对相关的危险因素进行分析。[方法]采用随机抽样的方法确定研究对象,并进行流行病学问卷调查,液基细胞学检查及阴道镜检查。如阴道镜下可疑病变则行活检。[结果]抚顺市宫颈癌及CIN的患病率为宫颈癌0.17%,CIN5.84%,CINⅡ-Ⅲ2.17%,抚顺农村为CIN2.83%,CINⅡ-Ⅲ0.67%;盘锦市CIN2.83%,CINⅡ-Ⅲ0.5%,盘锦农村CIN1.87%,CINⅡ-Ⅲ0.51%。抚顺市的患病率在四个筛查地点中明显居高。城市的患病率（宫颈癌0.08%,CIN4.34%,CINⅡ-Ⅲ1.33%）均高于农村（CIN2.35%,CINⅡ-Ⅲ0.59%）。CIN发病的高峰年龄在30-34岁和45-49岁,高峰职业在工厂手工业者。吸烟、初次性生活年龄小于21岁是CINⅡ-Ⅲ发生的高危因素。而教育程度、自然流产、人工流产、性伴侣的婚外性伴侣、生产史和避孕措施显示出不具有统计学意义。[结论]辽宁省抚顺市区的宫颈癌及CIN的患病率明显高于抚顺农村和盘锦市及农村,且高于沈阳市区,提醒我们应重点预防。吸烟、过早的性生活是我们应预防的高危因素。[ Purpose] To investigate risk factors and prevalence of cervical intraepithelial neoplasia （ClN） and cervical cancer in Fushun and Panjin city, Liaoning province. [Methods] Women were selected randomly, for an standard epidemiologic questionaire, liquid-based cytology examination and colposcopy. Colposcopy-directed biopsy were carried out for the case with suspicious colposcopy image. [Results] The prevalance was 0.17% for cervical cancer, 5.84% for ClN and 2.17% for ClN II -III in urban area of Fushun, and 2.83% for ClN, 0.67% for ClN II -III in rural area of Fushun. The prevalence was 2.83% for CIN, 0.5% for ClN II -III in urban area of Panjin, and 1.87% for CIN, 0.51% for ClN II -III in rural area of Panjin.The prevalence of Fushun was the highest. The prevalence in urban area （0.08% for cervical cancer, 4.34% for CIN and 1.33% for CIN II -III） was higher than that in rural area （2.35% for CIN and 0.59% for CIN II -III）.The peak risk ages for CIN were 30-34 years and 45-49 years old, and handicraft industry was the sensitive occupation. Smoking, and early sexual activity were the high-risk factor of CIN II -III. Education, abortion, multiple sex-partners and contraception methods did not show significant effect. [ Conclusion] The incidence of cervical cancer and CIN in Fushun urban area is significantly higher than that in Fushun rural area and Panjin areas, and also higher than that in Shenyang city. Smoking and early sexual activity are the high-risk factors for prevention.

关 键 词：宫颈癌 宫颈上皮内瘤变 辽宁 发病率 

分 类 号：R737.33[医药卫生—肿瘤]