上皮性卵巢癌组织中泛素与细胞周期蛋白B1的表达  

Expression of ubiquitin and Cyclin B1 in epithelial ovarian carcinoma tissue

作　　者：史惠蓉[1] 卫玲[2] 张瑞涛[1] 

机构地区：[1]郑州大学第一附属医院妇产科,郑州450052 [2]甘肃省肿瘤医院妇瘤科,兰州730050

出　　处：《郑州大学学报（医学版）》2010年第3期381-384,共4页Journal of Zhengzhou University(Medical Sciences)

基　　金：河南省医学科技攻关计划基金资助项目200703070

摘　　要：目的:检测上皮性卵巢癌组织中泛素(Ub)与细胞周期蛋白B1(Cyclin B1)的表达情况。方法:应用免疫组织化学SP法检测20例正常卵巢组织、20例卵巢良性肿瘤组织及50例上皮性卵巢癌组织中Ub和Cyclin B1蛋白的表达。结果:上皮性卵巢癌组织中Ub和Cyclin B1蛋白的阳性表达率分别为34.0%(17/50)和42.0%(21/50),与正常卵巢组织的5.0%(1/20)、5.0%(1/20)和卵巢良性肿瘤组织的10.0%(2/20)、15.0%(3/20)相比,差异有统计学意义(P=0.014;χ2=11.841,P=0.003)。上皮性卵巢癌组织中Ub和Cyclin B1蛋白的表达与FIGO分期(χ2=4.529,P=0.033;χ2=5.520,P=0.019)、分化程度(χ2=5.451,P=0.020;χ2=5.889,P=0.015)和淋巴结转移(χ2=6.269,P=0.012;χ2=6.226,P=0.013)有关。上皮性卵巢癌组织中Ub和Cyclin B1蛋白的表达有关联(χ2=5.451,rP=0.314,P=0.020)。结论:Ub和Cyclin B1可能协同参与上皮性卵巢癌的恶性进展和转移,可用于评估上皮性卵巢癌的恶性程度及预后。Aim：To investigate the expression and clinicopathologic significance of ubiquitin（Ub） and Cyclin B1 protein in epithelial ovarian carcinoma（EOC） tissue.Methods：Immunohistochemistry was used to detect the expressions of Ub and Cyclin B1 protein in 20 cases of normal ovary,20 cases of benign epithelial ovarian tumor,and 50 cases of EOC tissue.Results：The expressions of Ub and Cyclin B1 protein in EOC tissue were 34.0%（17/50） and 42.0%（21/50） respectively,which were different from those of normal ovary[5.0%（1/20） and 5.0%（1/20）] and benign epithelial tumor [10.0%（2/20） and 15.0%（3/20）]（P=0.014;χ2=11.841,P=0.003）. The expressions of Ub and Cyclin B1 in EOC tissue were associated with FIGO staging （χ2=4.529,P=0.033;χ2=5.520,P=0.019）,histological grading （χ2=5.451,P=0.020;χ2=5.889,P=0.015） and lymph node metastasis（χ2=6.269,P=0.012;χ2=6.226,P=0.013）.Ub expression was associated with Cyclin B1 expression in EOC tissue（χ2=5.451,rP=0.314,P=0.020）.Conclusion：Ub and Cyclin B1 may be involved in the malignant progression and metastasis of EOC,and could be used to evaluate the malignant degree and prognosis of EOC.

关 键 词：上皮性卵巢癌 泛素 细胞周期蛋白B1 

分 类 号：R733.71[医药卫生—肿瘤]