人乳头瘤病毒、疱疹病毒Ⅱ型及人巨细胞病毒与宫颈癌关系的研究  

INVESTIGATION OF THE ASSOCIATION OF HUMAN PAPILLOMA VIRUS,HERPES SIMPLEX VIRUS TYPE 2 AND HUMAN CYTOMEGALOVIRUS WITH CERVICAL CARCINOMA

作　　者：孟祥金[1] 孙瑜[2] 李文[1] 李昆[3] 韩日才[3] 曾维坤 刘朝奇[2] 

机构地区：[1]山东省医学科学院 [2]湖北医学院 [3]中国医学科学院 [4]湖北医学院附属第二医院

出　　处：《山东医科大学学报》1990年第2期27-30,共4页Acta Academiae Medicinae Shandong

摘　　要：用人乳头瘤病毒(HPV)16,18,11型、疱疹病毒Ⅱ型(HSV-2)N/BglⅡ,L/HindⅢ片段和人巨细胞病毒(HCMV)DNA等6个核酸探针,通过分子杂交技术对宫颈疾患活检标本进行了检测和分析,结果在同一标本中未发现3种病毒DNA均阳性者,但宫颈癌标本中46%HPV和HCMV DNA同时存在,2例HSV-2 DNA阳性的宫颈癌标本中有1例同时存在HCMV DNA。提示宫颈癌的病毒病因是多因素的,HPV,HSV-2和HCMV均可能有关,在宫颈癌发生过程中3者之间可能有某些内在联系。Biopsies from cervical lesions were detected and analysedby molecular hybridization technique using human papillomavirus(HPV)type 16,18,11,Herpes simplex virus type 2(HSV-2)N/Bgl Ⅱ,L/HindⅢ DNA fragments and human cytomegalovirus(HCMV)DNA probes.Theresults showed that HPV,HSV-2 and HCMV DNA sequences were not foundto be existent in the same samples,but HPV and HCMV DNA sequenceswere simultaneously present in about 46%(16/35)of cervical carcinoma,and one of the 2 HSV-2 DNA sequences positive samples was also exis- tent for HCMV DNA sequences.The results indicate that the viral etiologyof cervical carcinoma is ultifactorial;HPV,HSV-2 and HCMV may allassociate with cervical carcinoma,it may have some relationship among these 3 viruses.

关 键 词：子宫颈肿瘤 疱疹病毒 巨细胞病毒 

分 类 号：R737.330.2[医药卫生—肿瘤]