38例乳腺癌组织中酸性同功铁蛋白与P^(53)蛋白免疫组化的检测分析  

Immunohistochemical Acidic Isoferritin in Human Breast Carcinoma

作　　者：王桂华 易先平 

机构地区：[1]湖北省武汉市第二医院病理科,武汉430014

出　　处：《肿瘤防治研究》1999年第2期88-90,共3页Cancer Research on Prevention and Treatment

基　　金：武汉市科委资助课题

摘　　要：目的:为了探讨酸性同功铁蛋白在乳腺癌组织中的表达水平及其与P53表达的关系,明确酸性同功铁蛋白作为乳腺癌诊断指标的意义。方法:采用抗人胎盘酸性同功铁蛋白单克隆抗体和免疫组化方法(LSAB法)对38例乳腺癌和30例乳腺腺病组织进行了检测。结果:737%(28/38例)的乳腺癌和67%(2/30例)的乳腺腺病患者AIF呈阳性表达,阳性细胞胞浆着色明显,阳性细胞主要是癌细胞和增生的导管上皮细胞;447%(17/38例)的乳腺癌和33%(1/30例)的乳腺腺病组织P53呈阳性表达,阳性着色位于核内,阳性细胞为癌细胞和非典型增生的导管上皮细胞;P53表达与AIF表达符合率为605%,二者有一定的相关性(005<P<01)。结论:酸性同功铁蛋白的检测可以作为乳腺癌早期诊断指标之一。To study expression of acidic isoferritin (AIF) and it's relation with P 53 in human breast carcinoma.In present papers,38 cases of breast carcinoma and 30 cases of breast adenosis were examimated by immunohistochemical method (LSAB technique).The results were that 73 7percent (28/38 cases) of breast carcinoma and 6 7 percent (2/28cases) of breast adenosis showed positive stain of AIF,44 7 percent (17/38 cases) of breast carcinoma and 3 3 percent(1/30 cases) of breast adenosis showed positive stain of P 53 ,the same positive and negative accordance of AIF and P 53 was 60 5 percent(23/38 cases) in breast carcinoma.Conclusion:AIF may be a diagnostical index for breast carcinoma.

关 键 词：酸性铁蛋白 免疫组织化学 P53蛋白 乳腺癌 

分 类 号：R737.904[医药卫生—肿瘤]