胃肠道间质瘤促血管生成相关因子的检测及其意义  

Detection and Significance of Angiogenic Factors in Gastrointestinal Stromal Tumor

作　　者：张天彪[1] 赵滢[2] 赵毅[2] 关一夫[1] 

机构地区：[1]中国医科大学基础医学院生物化学与分子生物学教研室,沈阳110001 [2]中国医科大学附属盛京医院胃肠营养外科,沈阳110004

出　　处：《中国医科大学学报》2010年第5期359-361,共3页Journal of China Medical University

基　　金：辽宁省教育厅高校科研计划项目(2009A726)

摘　　要：目的研究胃肠道间质瘤(GIST)中促血管生成相关因子的检测及其意义。方法免疫组织化学法检测低氧诱导因子1α(HIF-1α)、一氧化氮合酶2(NOS2)及血管内皮生长因子(VEGF)在GIST中的表达。结果 HIF-1α、NOS2和VEGF的表达与GIST的NIH分级、肿瘤黏膜受侵及侵袭转移关系密切。有侵袭转移组的阳性率明显高于无侵袭转移组。HIF-1α、NOS2和VEGF的表达与其他临床病理特征无明显的相关性。HIF-1α与NOS2及VEGF蛋白阳性表达之间呈显著正相关。结论 HIF-1α、NOS2和VEGF表达可能是恶性肿瘤生长、侵袭、转移的重要指标。Objective To investigate the detection of the angiogenic factors in gastrointestinal stromal tumor（GIST）and its clinical significance. Methods The expressions of hypoxia-inducible factor-1α （HIF-1α）,nitric oxide synthase 2 （NOS2）,and vascular endothelial growth factor（VEGF）in GIST were detected by immunohistochemistry. Results The expressions of HIF-1α、NOS2,and VEGF were closely related to NIH classification,mucosal invasion,and lymphatic metastasis of GIST. The positive rate in metastatic tumor was much higher than that in non-metastatic tumor. The expressions of HIF-1α,NOS2,and VEGF were not significantly correlated with other clinical pathological characteristics. Conclusion The expressions of HIF-1α,NOS2,and VEGF may be indicators of the growth,invasion,and metastasis of malignant tumors.

关 键 词：胃肠道间质瘤 低氧诱导因子1Α 血管生成 侵袭 转移 

分 类 号：R735.2[医药卫生—肿瘤]