后路外滤过术对正常兔眼前房及其切口相关组织形态学研究  

Experimental study on incision-related morphology in normal rabbits of pars plana filtration technique

作　　者：吴烈[1] 桑子谨[1] 杨迎新[1] 李理[1] 周浩川[1] 唐聪[2] 胡晓丹[2] 

机构地区：[1]中国中医科学院广安门医院,北京100053 [2]中国中医科学院广安门医院眼科

出　　处：《中国中医眼科杂志》2010年第3期130-133,共4页China Journal of Chinese Ophthalmology

基　　金：中国中医科学院广安门医院所级基金支助项目(2005S109)

摘　　要：目的探讨后路切口(睫状体平坦部)外滤过术在房水引流过强情况下对正常兔眼前房及其相关组织形态学的影响。方法将5只(10眼)正常兔分为2组,每组各5眼,以小梁切除术作为对照(前路组),采用后路睫状体平坦部切口的外滤过术式(后路组),均在切口较大、滤过通道完全开放、房水引流过强的情况下利用眼超声生物显微镜(UBM)与眼B超测量术后兔眼前房深度及相关组织形态学变化情况。结果术后第1～3天,前路组中央前房明显变浅且低于正常值范围,周边前房消失。后路组前房较正常范围加深,两组间比较差异有统计学意义(P<0.01);术后7～15天,前路组中央前房深度略有加深,周边前房可见,但前房深度小于后路组(P<0.05);术后30天,前路组中央前房深度仍小于后路组,但组间比较差异无统计学意义(P>0.05)。UBM检查见前路组术后15天,滤过泡不明显,巩膜切口轻度粘连;术后30天,未见滤过泡,巩膜切口粘连,滤过道关闭;后路组术后15～30天,滤过泡局限、腔小,巩膜切口轻度粘连,滤过道狭窄但未完全关闭。B超二组兔眼内均未见玻璃体机化及脉络膜、视网膜脱离等并发症。结论后路切口(睫状体平坦部)外滤过术可以做较大切口,满足较大房水引流量的需要,同时延缓滤过通道发生瘢痕闭合,用于治疗难治性青光眼安全、可靠。OBJECTIVE To investigate the ocular region morphology in normal rabbits of pars plana filtration technique,identify the security of pars plana incision and provide new methods to clinical treatment. METHODS Ten normal eyes were divided into two groups,5 eyes as the treatment group （group 1） received pars plana filtration surgery,others as control group （group 2） received trabeculectomy. To investigate the anterior segment and appearance of the bleb in the condition of overfiltration,observe the intraocular tissue and measure the depth of anterior chamber with ultrasonography. RESULTS From 1st to 3rd postoperative day,group 2 had complication with flat chamber but group 1 had anterior chamber deepened,there was significant difference between two groups （P0.01）. From 7th to 15th day,anterior chamber of group 2 deepened a lot but still shallower than group 1,and there＇s still.

关 键 词：睫状体平坦部切口 外滤过术 兔眼组织形态学 

分 类 号：R779.62[医药卫生—眼科] R332[医药卫生—临床医学]