Ang-2、VEGF在乳腺癌中的表达及意义  

The significance of Ang-2 and VEGF expressions in breast cancer

作　　者：宋聚民 王晓丰 张世斌 

机构地区：[1]山东省成武县人民医院普外科,山东成武274200

出　　处：《现代肿瘤医学》2010年第6期1126-1128,共3页Journal of Modern Oncology

摘　　要：目的:探讨Ang-2、VEGF表达与乳腺癌临床病理特征的关系,分析二者表达的相关性。方法:采用免疫组化SABC法检测46例乳腺浸润性导管癌和10例乳腺纤维腺瘤组织中Ang-2、VEGF的表达水平。结果:46例乳腺癌组织中Ang-2、VEGF表达阳性率分别为56.5%、65.2%,高于乳腺纤维腺瘤。Ang-2、VEGF的表达水平与乳腺癌组织学分级显著相关;腋窝淋巴结转移组Ang-2、VEGF表达阳性率高于无转移组;Ang-2、VEGF在ER/PR阴性组和阳性组的表达有显著差异。Ang-2、VEGF的表达相互之间显著相关。结论:乳腺癌组织中Ang-2、VEGF表达上调,在乳腺癌发生、发展过程中具有重要作用。Ang-2、VEGF协同刺激乳腺癌血管生成,可能是促进乳腺癌发生转移的重要机制。Ang-2可能成为判断乳腺癌预后的重要指标。Objective： To investigate the expressions of Ang - 2 and VEGF in breast cancer and its correlations with clinicopathological characteristics, and the association of Ang - 2 and VEGF in breast cancer. Methods： Expressions of Ang - 2 and VEGF in 46 breast invasive ductal carcinoma and 10 breast fibroadenoma spicemens were detected by immunohistochemical method（SABC）. Results： Ang - 2 and VEGF positive expression rates were 56. 5% and 65.2% in 46 breast carcinomas respectively, which were significantly higher than in breast fibroadenomas. In high histological grade diseases Ang - 2 and VEGF positive rates were significantly higher than in low grade diseases. Ang - 2 and VEGF positive expressions were associated with axillary lymph node metastases. Ang - 2 and VEGF pos- itive rates were significantly higher in ER/PR negative group than in positive group. Significant correlations were found between Ang - 2 and VEGF expressions. Conclusion： Ang - 2 and VEGF over - expressions in breast caicinoma were significantly correlated with occurrence, development of breast cancer. Ang- 2 and VEGF cooperate in promoting the vascular growth of breast cancer. Ang -2 might serve as a valuable prognostic indicator in breast cancer.

关 键 词：血管生成素-2 血管内皮生长因子 乳腺癌 免疫组化 

分 类 号：R737.9[医药卫生—肿瘤]