大肠癌患者血清基质金属蛋白酶-7含量的临床意义(英文)  

Clinical significance of serum matrix metalloproteinases-7 in patients with colorectal carcinoma

作　　者：王春雷[1,2] 万远廉[1] 戴悦[3] 汪欣[1] 刘玉村[1] 范宝英 郑妍妍 

机构地区：[1]北京大学第一医院普通外科,北京100034 [2]北京崇文第一人民医院内科,北京100075 [3]北京大学第一医院血液中心,北京100034

出　　处：《现代肿瘤医学》2010年第6期1160-1164,共5页Journal of Modern Oncology

基　　金：中国博士后科学基金资助项目(编号:20073138)

摘　　要：目的:评估大肠癌患者血清MMP-7含量及其临床意义。方法:术前应用免疫酶联反应技术对50例大肠癌患者以及36例健康对照者的血清MMP-7含量进行检测,同时也检测这些患者血清CEA、CA19-9以及CA24-2含量。将大肠癌患者的血清MMP-7及其它肿瘤标志物的含量与健康对照者进行了比较。对不同临床病理分期的大肠癌患者血清MMP-7含量进行评估。结果:研究发现多数大肠癌患者的血清MMP-7含量升高。大肠癌患者的血清MMP-7含量,分布范围0.72-28.69ng/ml(平均4.41ng/ml;中位4.19ng/ml),显著高于健康对照者,分布范围0.69-3.97ng/ml(平均1.62ng/ml;中位1.36ng/ml)(P<0.01)。大肠癌患者的血清MMP-7平均阳性率(46%)与CEA(30%),CA19-9(26%)及CA24-2(24%)相比均升高(P<0.05)。进展期肿瘤患者血清MMP-7含量显著高于早期肿瘤患者(P<0.05)。结论:血清MMP-7有可能成为大肠癌患者临床监测标志物。Objective： To evaluate serum levels of MMP -7 and its clinical significance in patients with colorectal carcinoma. Methods：MMP -7 in serum was examined prior to surgery on 50 patients with colorectal cancer as well as from 36 healthy normal controls by using a quantitative sandwich enzyme immunoassay technique, and serum carcino-embryonic antigen （CEA）, CA19 -9 and CA24 -2 levels were also examined in the same patients. Serum MMP -7 levels in colorectal carcinoma patients were compared with other tumor markers as well as that in healthy controls. In addition, MMP-7 serum concentrations in patients with different clinicopathological stages of colorectal carcinoma were also evaluated. Results：The majority of the patients with colorectal carcinoma were found to have high concentrations of serum MMP -7. MMP -7 levels in patients with colorectal cancer, ranged from 0.72 -28.69ng/ml （mean, 4.41ng/ml; median, 4. 19ng/ml） , were significantly higher than levels in sera from healthy individuals, ranged from 0.69 to 3.97 ng/ml （mean, 1.62ng/ml; median, 1.36ng/ml） （P〈0.01）. The mean positive percentage of MMP -7 （46%） compared with CEA （30%） , CA19 -9 （26%） and CA24 -2 （24%） serum concentration being higher in colorectal patients （P〈0. 05）. MMP -7 serum concentrations of patients with advanced stage carcinoma were significantly higher compared to patients with early stage cancer （P 〈0.05）. Conclusion;The present data indicate that the elevation of serum levels of MMP - 7 may be a useful marker for clinical monitoring of colorectal carcinoma patients.

关 键 词：基质金属蛋白酶-7 大肠癌 血清 肿瘤标志物 

分 类 号：R735.34[医药卫生—肿瘤]