上皮钙黏蛋白与β-连环素在舌鳞状细胞癌中的表达及其与预后的关系  

Expression of E-cadherin and β-catenin in oral squamous cell carcinomas of tongue ： correlation with the clinicopathologic features and patient prognosis

作　　者：朱锐[1] 姜小云[1] 宋晓陵[1] 张玮[1] 陈盛[1] 刘来奎[1] 

机构地区：[1]南京医科大学口腔医学研究所南京医科大学附属口腔医院口腔基础教研室,210029

出　　处：《中华口腔医学杂志》2010年第5期295-298,共4页Chinese Journal of Stomatology

基　　金：国家自然科学基金（30872903）;江苏省卫生厅科研项目（H200753）志谢 南京医科大学附属口腔医院口腔病理科张平技师,学生周向向、吴荧荧及第四军医大学统计学教研室李婵娟讲师

摘　　要：目的 研究舌鳞状细胞癌（舌癌）中上皮钙黏蛋白（E—cadherin，E—cad）、β-连环素（β-catenin）的表达，探讨其在舌癌复发及预后中的意义。方法采用免疫组化半定量方法检测30例舌癌患者肿瘤组织中E-cad与β-连环素的表达，同时通过随访资料分析其表达水平与临床病理及预后之间的关系。结果63％（19／30）的癌组织中E—cad呈低表达；60％（18／30）癌组织中β-连环素高表达。E—cad、β-连环素表达水平与患者的性别、年龄、肿瘤分化程度、大小、临床分期、淋巴结转移比较，差异无统计学意义；E—cad表达与肿瘤复发比较，差异有统计学意义（P=0．007），而β-连环素表达与肿瘤复发比较，差异无统计学意义（P〉0．05）。单因素Cox回归预后分析显示E—cad的表达与生存率比较，差异有统计学意义（P=0．018）。结论E—cad表达降低与肿瘤复发及术后生存率之间密切相关，可作为舌癌患者预后的预测指标。Objective To examine the E-eadherin and β-eatenin expression in oral squamous cell carcinoma of tongue（OSCCT） and investigate the relationship of these markers with clinicopathologic features and patient prognosis. Methods Quantitative immunohistochemistry analysis was used to examine E-cadherin and β-catenin expression in lesions of 30 OSCCT patients, The relationship between the expression of E-cadherin and β-catenin and clinicopathologicical features was analyzed. Results The decreased expression of E-cadherin was observed in 19 of 30 （63%） tumours from patients who eventually developed a recurrent tumour and was also associated with recurrence （ P = 0. 007） . The expression of E-cadherin was associated with survival （P = 0. 0l 8） and an independent prognostic factor in univariate analysis. There was no correlation between the expression level of E-cadherin and sex, age, histological differentiation, turnout size, clinical stage, or lymph node metastasis. The high expression of β-catenin was observed in 18 of 30 （60%） tumours. No correlation between β-catenin expression and elinieopathological features was observed. Conclusions The absence or reduced expression of E-cadherin was closely associated with recurrence and survival in OSCCT patients. The aberrant expression of E-cadherin may provide a useful prognostic marker in OSCCT.

关 键 词：癌 鳞状细胞 钙黏着糖蛋白 Β连环素 

分 类 号：R739.8[医药卫生—肿瘤]