以罗马Ⅲ标准为基础的功能性消化不良临床研究  

A Clinical Study on Functional Dyspepsia Based on Rome Ⅲ Criteria

作　　者：杨霞[1] 柏愚[1] 邹多武[1] 李兆申[1] 

机构地区：[1]第二军医大学附属长海医院消化内科

出　　处：《胃肠病学》2010年第5期292-295,共4页Chinese Journal of Gastroenterology

摘　　要：背景：功能性消化不良（FD）发病率较高,自2006年罗马Ⅲ标准发布以后,中国大陆地区关于FD的临床研究并不多见.目的：探讨以罗马Ⅲ标准为基础的FD的临床特征.方法：选取2009年4月～2010年4月上海长海医院收治的符合罗马Ⅲ标准的100例FD患者,对其一般情况、治疗效果、重叠症相关因素等进行分析.结果：100例FD患者以女性多见,平均发病年龄（40.9±12.3）岁.根据症状分型,餐后不适综合征（PDS）患者30例,上腹痛综合征（EPS）22例,混合型48例.行对症治疗后,71.0%的FD患者症状消失.随着体重指数（BMI）升高,FD患者的消化不良症状呈加重趋势,但差异无统计学意义（P=0.08）.38.0%的FD患者重叠肠易激综合征（IBS）,22.0%重叠胃食管反流病（GERD）.FD重叠IBS患者的餐后胞胀不适发生率明显高于单独FD患者（P=0.02）.结论：对症治疗可使多数FD患者的症状改善,BMI可能与FD症状有关.FD重叠IBS患者的餐后饱胀不适发生率显著高于单独FD患者.Background： Functional dyspepsia （FD） is a highly prevalent disease, but there are only few published reports on FD in China after the issue of Rome Ⅲ criteria in 2006. Aims： To appraise the clinical characteristics of FD based on Rome Ⅲ criteria. Methods： One hundred FD patients diagnosed by Rome Ⅲ criteria from April 2009 to April 2010 at Shanghai Changhai Hospital were enrolled. General condition, therapeutic effect and correlated factors of overlapping disorders were analyzed. Results： FD was more prevalent in female patients with a mean age of （40.9±12.3） years. The categorization of subgroups was based on symptoms： postprandial distress syndrome （PDS） 30 cases, epigastric pain syndrome （EPS） 22 cases and PDS＋EPS 48 cases. Symptoms disappeared in 71.0% of cases after appropriate symptomatic treatment. There was a trend of aggravation of symptoms with increase of body mass index （BMI）, but not reaching statistical significance （P=0.08）. Of the FD patients, 38.0% showed coexistent irritable bowel syndrome （IBS）, and 22.0% had coexistent gastroesophageal reflux disease （GERD）. Incidence rate of postprandial fullness in patients with FD ＋ IBS was significantly higher than that in FD patients （P=O.02） Conclusions： Symptomatic treatment can improve symptoms of most FD patients. Probably there is a positive association between increase of BMI and symptom of FD. Incidence rate of postprandial fullness in patients with FD ＋ IBS is significantly higher than that in FD patients.

关 键 词：罗马Ⅲ标准 消化不良 治疗 人体质量指数 

分 类 号：R57[医药卫生—消化系统]