脉冲强磁场对小鼠移植性实体瘤杀伤作用的实验研究  

Experimental study on injurious effect of strong impulse magnetic field on implanted solid tumor in mice

作　　者：王群 胡大为 范志民 邹本荣 高德奎 刘传谨 刘国津 

出　　处：《白求恩医科大学学报》1999年第1期18-20,共3页Journal of Norman Bethune University of Medical Science

摘　　要：目的：探讨交变脉冲强磁场对肿瘤组织杀伤作用的机理。方法：应用交变脉冲强磁场对３０只接种Ｌｏｕｉｓ肺癌的昆明小鼠作了杀伤实验研究。对实验组与对照组荷瘤鼠抑瘤率和抑瘤曲线进行观察。结果：两组肿瘤生长曲线存在明显差异（Ｐ＜００５）。两组肿瘤生长体积和肿瘤重量均存在明显差异（Ｐ＜００１）。肿瘤体积抑制率＝５２９４％，肿瘤重量抑制率＝３７２４％。结论：交变脉冲强磁场对肿瘤组织细胞具有选择性杀伤作用和抑制肿瘤生长作用。提示脉冲强磁场可能成为治疗癌症的一个新的物理疗法。Objective:In order to investigate the mechanism of injurious effect of alternation impulse magnetic field on tumor.Methods:The study was carried out with 30 kunming mice inoculated lung cancer via alternating impulse magentic field.The tumor suppressing rate and tumor suppressing curves were observed between experimental group and control group.Results:The results showed that there were significant differences in tumor growth curve ( P <0 05),tumor weights and tumor volumes ( P <0 01).The tumor suppressing rate of tumor volume and weight were 52.94% and 37.24% respectively. Conclusion:The results revealed selective injury effect and suppressing growth effect of alternating impulse magnetic field on tumor cells.It is possible that strong alternating impulse magnetic field become a new therapeutic method of malignant tumor.

关 键 词：脉冲磁场 肿瘤 移植瘤 实体瘤 杀伤作用 

分 类 号：R73－36[医药卫生—肿瘤] R73－33[医药卫生—临床医学]