血清Ⅲ、Ⅳ型胶原及板层素对肝纤维化的诊断价值  

Evaluation of the PCⅢ,Ⅳ C and LN level in diagnosis of hepatic fibrosis

作　　者：李漫松[1] 迟宝荣 冯露[1] 

机构地区：[1]长春税务学院卫生所

出　　处：《白求恩医科大学学报》1999年第1期66-67,共2页Journal of Norman Bethune University of Medical Science

摘　　要：目的：探索诊断早期肝纤维化的敏感指标。方法：用放射免疫法检测２３６例各型肝病患者血清Ⅲ型胶原（ＴｐｙｅⅢｃｏｌａｇｅｎ，ＰＣⅢ）、Ⅳ型胶原（ＴｐｙｅⅣｃｏｌａｇｅｎ，Ⅳ－Ｃ）和板层素（Ｌａｍｉｎｉｎ，ＬＮ）水平。结果：各类肝病患者血清ＰＣⅢ、Ⅳ－Ｃ和ＬＮ水平随病情进展而逐渐升高。以ＰＣⅢ≥１３５μｇ／Ｌ、Ⅳ－Ｃ≥１３０μｇ／Ｌ为诊断肝纤维化的临界点，其敏感度、特异性、准确率分别达８０％以上。结论：表明ＰＣⅢ、Ⅳ－Ｃ及ＬＮ可作为肝纤维化诊断较为敏感的指标，其中Ⅳ－Ｃ对早期肝纤维化的诊断优于ＰＣⅢ及ＬＮ。Objective:To survey the sensitive marker in diagnosis of hepatic fibrosis.Methods:The serum levels of Type Ⅲ collagen (PCⅢ),Tpye Ⅳ collagen (Ⅳ C) and lamini (LN) of 236 patients with hepatic diseases were tested in the study with RIA.Results:The results showed that serum concentrations of PCⅢ,Ⅳ C and LN in diffrent stages gradually increased with the progression of liver damage.The cut off points with Ⅳ C≥130 μg/L,PCⅢ≥135 μg/L and LN≥ 160 μg/L were found the best in diagnosis of hepatic fibrosis with the sensitivity,the specificity and the accuracy over 80%.Conclusion:The results indicate that serum PCⅢ,Ⅳ C and LN are sensitive markers in diagnosis of hepatic fibrosis.Among these parameters,Ⅳ C is better than others in early diagnosis of liver fibrosis and it would be helpful in diagnosis of liver cancer.

关 键 词：肝纤维化 Ⅲ型胶原 Ⅳ型胶原 板层素 诊断 

分 类 号：R575.204[医药卫生—消化系统]