2-羟基吡啶的合成工艺  

The Synthetic Technology of 2-Hydroxylpyridine

作　　者：张丹丹[1] 瞿军 陆文辉 张符 吴宏祥 宋祥波[1] 朱幸丹[1] 钱豪[1] 

机构地区：[1]浙江省绍兴文理学院化学化工学院,浙江绍兴312000 [2]江苏省扬州普林斯化工有限公司,江苏扬州225654

出　　处：《河北化工》2010年第6期48-49,共2页Hebei Chemical Industry

摘　　要：用2-氯吡啶与KOH在乙二醇中反应得到2-羟基吡啶的碱金属盐,再经中和得目标产物2-羟基吡啶。采用溶解度好、沸点合适的乙二醇作溶剂,不仅对原料2-氯吡啶的溶解度较好,还对KOH具有较好的溶解效果,使得反应能均相进行。该工艺操作简单,反应条件温和,副产物少,产品总收率达到90.4%。Alkali metal salt of 2-hydroxypyridine can be obtained by the reaction of 2-chloropyridine and KOH in ethylene glycol,and 2-hydroxylpyrine was also got by neutralization with HCl.This technology uses ethylene glycol as solvent,that has good solubility and suitable boiling point.By this method,simple operation,mild conditions and less by-product were observed.The overall yield is 90.4%.

关 键 词：2-羟基吡啶 2-氯吡啶 乙二醇 

分 类 号：TQ253.2[化学工程—有机化工]