老年痴呆与ApoE基因多态性分布的研究  

Association Between Polymorphism of Apoliprotein E and Senile Dementia

作　　者：刘静波[1] 俞顺章[1] 张幼辰[1] 贺风风[1] 卫国荣[1] 

机构地区：[1]上海医科大学公共卫生学院预防医学研究所

出　　处：《中国公共卫生》1999年第1期13-14,共2页Chinese Journal of Public Health

摘　　要：为了解ＡｐｏＥ基因型在上海老年痴呆患者中的分布情况，进一步揭示ＡｐｏＥ基因多态性和老年痴呆的关系，对４１例老年痴呆患者及４２例正常老年人，用ＰＣＲ－ＲＦＬＴ方法作了有关ＡｐｏＥ基因型的检测。结果发现，病例组中ＡｐｏＥ的Ｅ４等位基因频率显著高于对照组，ＯＲ值为３．６６（９５％ＣＩ为１．５３～８．９１），提示等位基因Ｅ４是老年痴呆的危险因素。In an effort to explore the distribution of ApoE genotype in senile dementia patient and to show up the association of polymorphism of ApoE and the senile dementia,we have undertaken case control studies of the subjects of senile dementia(n=41) and normal controls(n=42),the statues of ApoE gene was determined by PCR RFLP method,we found that the E4 allele of ApoE was significantly more frequent in senile dementia patients than in controls (P<0 01,OR=3 66,95%CI:1 53～8 91),the findings suggested that E4 allele of ApoE is a risk factor of senile dementia

关 键 词：痴呆 老年性痴呆 APOE基因 基因多态性 

分 类 号：R749.16[医药卫生—神经病学与精神病学]