阿立哌唑与舍曲林治疗强迫障碍的对照研究  

Control study of Aripiprazole and Sertraline treatment of obsessive compulsive disorder

作　　者：徐海春[1] 高林[1] 王雪宏[1] 

机构地区：[1]沈阳市于洪区红十字会医院心理科,辽宁沈阳110033

出　　处：《中国民康医学》2010年第12期1495-1495,1580,共2页Medical Journal of Chinese People’s Health

摘　　要：目的:观察阿立哌唑与舍曲林治疗强迫障碍的疗效及安全性。方法:将36例强迫障碍患者随机分为研究组与对照组各18例,分别给予阿立哌唑口腔崩解片或舍曲林片治疗,疗程8周。采用耶鲁-布郎强迫量表、副反应量表评定临床疗效与不良反应。结果:治疗2、4、6、8周末研究组耶鲁-布郎强迫量表评分较治疗前下降明显(P<0.05),提示阿立哌唑疗效明显。治疗8周末研究组有效率80%,对照组85%,两组疗效相当(P>0.05)。两组不良反应均轻微。结论:阿立哌唑治疗强迫障碍的疗效与舍曲林相当,耐受性良好。Objective：To explore the efficacy and safety of Aripiprazole and Sertraline treatment of obsessive compulsive disorder.Methods：36 cases with obsessive compulsive disorder were randomly divided into Aripiprazole（n=18） and Sertraline（n=18） group for 8 weeks.The efficacy and side effects were assessed with Yale-Brown Obsessive-compulsive Scale（Y-Bocs） and TESS respectively.Results： Both groups showed significant efficacy in the treatment of obsessive compulsive disorder（P〈0.01或P〈0.05） and the total efficacy was no significant difference between the two groups（P〉0.05）,the side effects of Aripiprazole were few and slight than Sertraline（P〈0.05）.Conclusion：Aripiprazole is a very effective and safe antipsychotics in the treatment for obsessive compulsive disorder.

关 键 词：难治性强迫症 舍曲林 阿立哌唑 

分 类 号：R749.79[医药卫生—神经病学与精神病学]