Asymmetric epoxidation of α,β-unsaturated ketones using α,α-diarylprolinols as catalysts  

作　　者：ZHENG ChangWu ZHAO Gang 

机构地区：[1]Key Laboratory of Synthetic Chemistry of Natural Substances, Shanghai Institute of Organic Chemistry, Chinese Academy of Sciences, Shanghai 200032, China

出　　处：《Chinese Science Bulletin》2010年第17期1712-1722,共11页

基　　金：supported by the National Natural Science Foundation of China (20172064, 203900502, 20532040);QT Program, Shanghai Natural Science Council, and Excellent Young Scholars Foundation of the National Natural Science Foundation of China (20525208)

摘　　要：Asymmetric epoxidation of α,β-unsaturated ketones has been extensively studied and several important procedures have been developed in the last decade. This review addresses the most significant advances in asymmetric epoxidation of α,β-unsaturated ketones using proline-derived α,α-diarylprolinols as catalysts. Special attention has been paid to the enantioselective epoxidation of chalcones, α,β-unsaturated trifluoromethyl, trichloromethyl ketones and β,γ-unsaturated α-keto esters based on the reseach of our group.Asymmetric epoxidation of α, β-unsaturated ketones has been extensively studied and several important procedures have been developed in the last decade. This review addresses the most significant advances in asymmetric epoxidation of α, β-unsaturated ketones using proline-derived α,α-diarylprolinols as catalysts. Special attention has been paid to the enantioselective epoxidation of chalcones, α, β-unsaturated trifluoromethyl, trichloromethyl ketones and β, γ-unsaturated α-keto esters based on the reseach of our group.

关 键 词：β-不饱和酮 不对称环氧化 催化剂 对映选择性 三氟甲基 脯氨酸 查尔酮 甲基酮 

分 类 号：O643.3[理学—物理化学]