大肠癌中MTA1和HIF-1α的表达与淋巴管生成的关系  

Correlation of MTA1 and HIF-1α Expression with Lymphangiogenesis in Colorectal Carcinoma

作　　者：杨珍玉[1] 周序珑 夏明汗[2] 蒋光喻[2] 钟雪云[1] 杜彬[1] 

机构地区：[1]暨南大学医学院病理学系,广东广州510632 [2]暨南大学附属第一医院病理科,广东广州510632

出　　处：《中山大学学报（医学科学版）》2010年第3期350-353,396,共5页Journal of Sun Yat-Sen University:Medical Sciences

基　　金：广东省医学科研基金(B2006084)

摘　　要：【目的】探讨大肠癌中转移相关基因1(MTA1)、缺氧诱导因子-1α(HIF-1α)蛋白的表达及其与淋巴管生成的关系。【方法】用免疫组织化学SP法检测81例大肠癌中MTA1、HIF-1α蛋白的表达及D2-40标记的淋巴管密度。【结果】81例大肠癌中MTA1、HIF-1α阳性表达率分别为66.7%和63%,MTA1和HIF-1α的表达均与大肠癌Duke's分期和淋巴结转移相关(P<0.05)而与组织学分级和浸润深度无关(P>0.05),大肠癌中MTA1和HIF-1α蛋白表达呈正相关(P<0.05),MTA1和HIF-1α蛋白过表达病例肿瘤旁淋巴管密度分别为18.4±4.9、18.0±5.3,高于MTA1和HIF-1α不表达和弱表达病例(15.6±4.5、15.4±4.2),两者的差异有统计学意义(P<0.05)。【结论】MTA1和HIF-1α蛋白的过表达可能促进了大肠癌旁淋巴管的生成,在肿瘤淋巴结的转移中起一定作用。【Objective】To investigate the expression of metastasis-associated gene 1（MTA1）,hypoxia inducible-factor l alpha（HIF-1α）in human colorectal cancer and to explore the relationship between their expression and lymphangiogenesis.【Methods】The expression of MTA1 and HIF-1α,and D2-40 marked lymphatic vessel density（LVD）were detected by immunohistochemical staining in eighty-one human colorectal cancer cases.【Results】The positive rates of MTA1 and HIF-1α expression were 66.7%and 63.0%respectively in the eighty-one human colorectal cancer cases.The expression of MTA1 and HIF-1αwere both correlate with Duke＇s stage and lymph node metastasis（P0.05）but did not correlate with the pathological grade and depth of invasion（P0.05）.In addition,MTA1 and HIF-1αexpression has a positive correlation in human colorectal cancer（P0.05）.In MTA1 and HIF-1αover-expression cases,the peritumoral LVD was 18.4±4.9 and 18.0±5.3 respectively and was higher than that of the MTA1 and HIF-1αexpression none or weak cases（15.6±4.5,15.4±4.2）,the difference has statistically significance（P0.05）.【Conclusion】The overexpression of MTA1 and HIF-1αin colorectal cancer possibly promote the cancer lymphangiogenesis and play a role in lymph node metastasis.

关 键 词：结直肠癌 MTA1 HIF-1Α 淋巴管密度 

分 类 号：R735.34[医药卫生—肿瘤]