CD44在口腔鳞癌中的表达  

CD44 expression in oral squamous cell carcinoma

作　　者：李建华[1] 王学玖[1] 韩正学[1] 葛丽华[2] 邢汝东[1] 

机构地区：[1]首都医科大学口腔医学院口腔颌面外科,北京100050 [2]首都医科大学口腔医学院北京口腔医学研究所,北京100050

出　　处：《北京口腔医学》2010年第3期149-151,共3页Beijing Journal of Stomatology

摘　　要：目的初步探讨CD44分子在口腔鳞癌中的表达情况。方法以免疫组织化学方法对22例口腔不同部位的鳞癌及其周边扩大切除的组织进行了观察研究,并和癌组织的病理分级进行对比分析。结果 CD44表达在正常口腔粘膜表皮的基底细胞和部分棘层细胞的细胞膜上,同时在淋巴细胞上强表达。在鳞癌上皮组织中CD44的表达模式发生紊乱,表达水平与细胞分化程度有关,病理分化度较差的癌组织中CD44的表达逐渐减弱。结论 CD44可以作为评价口腔鳞癌恶性度的一个指标。Objective To examine the expression of CD44 in oral squamous cell carcinoma.Methods Samples of 22 oral SCC and their neighboring incised mucosa were collected and immunohistochemically stained for the expression of CD44.CD44 expression in lesions with different differentiation was compared and analyzed.Results CD44 was expressed in basal and some prickle layer cells of normal mucosa and strongly expressed in lymphocytes as well.The expression of CD44 varied with different differentiation of the SCC tissues,presenting down-regulation in the poor differentiated tissues.Conclusion CD44 could be used as one of the markers for the malignant degree of the oral squamous cell carcinoma.

关 键 词：CD44 口腔鳞癌 预后 

分 类 号：R739.8[医药卫生—肿瘤]