颅内血管外皮细胞瘤囊变坏死与P73表达相关性的研究  

Correlation between cystic necrosis of cranio-hemangiopericytoma and the expression of P73

作　　者：魏晓辉 周俊林[2] 黎卫平[3] 董驰[2] 

机构地区：[1]兰州市第一人民医院CT室,甘肃兰州730050 [2]兰州大学第二医院,甘肃兰州730030 [3]兰州大学基础医学院病理教研室,甘肃兰州730000

出　　处：《中国临床医学影像杂志》2010年第1期9-12,共4页Journal of China Clinic Medical Imaging

基　　金：兰州市科技计划项目(项目编号:07-1-84)

摘　　要：目的:探讨颅内血管外皮细胞瘤(HPC)的MRI表现囊变坏死与P73因子表达的相关关系。方法:采用免疫组织化学法(S-P法),用抗P73抗体对29例颅内HPC组织标本进行标记并分析,对肿瘤MRI图像上囊变坏死情况进行评分,对照做相关分析。结果:29例颅内HPCP73均呈阳性表达,与对照组血管瘤型脑膜瘤组之间具有统计学意义(P<0.01);随着肿瘤囊变坏死MRI评分的增高,P73阳性表达水平也提高(P<0.05)。结论:颅内HPCMRI表现囊变坏死与P73的表达程度相关,可做为分析肿瘤治疗和预后的参考。Objective：To investigate the correlation between cystic necrosis and P73 protein expression in cerebral hemangiopericytoma.Methods：Twenty-nine cases with intracranial hemangiopericytoma were chosen,25 cases of angiomatous type meningioma were also enrolled as control group.All cystic or necrotic signs on MRI of the two tumors were analyzed,which were scored according to Asari＇s method.P73 protein expressions were detected by S-P immunohistochemical method.Results：Twenty-nine cases showed positive expression,and there was significant difference in the expression of P73 between intracranial hemangiopericytoma and angiomatous type meningioma（P0.01）.The positive expression of P73 protein increased with increasing of cystic or necrotic signs on MRI of intracranial hemangiopericytoma（P0.05）.Conclusions：Cystic or necrotic sign on MRI was closely related to the high expression of P73 protein in intracranial hemangiopericytoma,which can been used as reference information evaluating the treatment and prognosis of intracranial hemangiopericytoma.

关 键 词：脑肿瘤 血管外皮细胞瘤 基因 磁共振成像 

分 类 号：R739.41[医药卫生—肿瘤] R445.2[医药卫生—临床医学]