自体骨髓单个核细胞移植对肝硬化患者血清白蛋白的影响  

Effect of autologous bone marrow mononuclear cells transplantation for serum albumin in patients with liver cirrhosis

作　　者：王帅[1] 姚鹏[1] 龚丽娟[1] 李树玲[1] 胡学玲[1] 闻炜[1] 胡大荣[1] 

机构地区：[1]北京军区总医院全军肝病治疗中心,北京100700

出　　处：《胃肠病学和肝病学杂志》2010年第6期509-512,共4页Chinese Journal of Gastroenterology and Hepatology

摘　　要：目的探讨经肝动脉插管自体骨髓单个核细胞(BM-MNCs)移植对肝硬化患者血清白蛋白(ALB)的影响。方法 201例肝硬化患者中,131例进行自体骨髓单个核细胞移植,70例为对照。骨穿采集自体骨髓,分离纯化单个核细胞将其经肝动脉插管移植入肝脏。分别于移植后4、8、12及24周观察ALB变化情况,比较不同Child-Pugh分级肝硬化患者ALB的改变。结果移植组患者移植前血清ALB平均为(29.33±3.92)g/L,移植后第4、8、12、24周分别为(32.37±4.63)g/L、(32.82±4.84)g/L、(32.95±5.10)g/L和(32.22±5.87)g/L。移植后24周内血清ALB水平较移植前显著升高,而对照组则无明显变化,两组比较差异有统计学意义。移植组中,Child-PughA、B级患者血清ALB改善程度大于C级患者。移植后无严重不良事件发生。结论自体骨髓单个核细胞移植能提高肝硬化患者血清ALB水平,对Child-PughA、B级患者改善明显。Objective To investigate the effect of autologous bone marrow mononuclear cells（BM-MNCs）transplantation for serum albumin（ALB）patients with liver cirrhosis.Methods In this study,201 patients with liver cirrhosis were included.Autologous BM-MNCs transplantation was carried on 131 cases of these patients and 70 cases were controls.Their bone marrow were aspirated and BM-MNCs were isolated by density grads centrifuge.A mean（5.51±2.63）×108 mononuclear cells were infused to patients by intubatton through hepatic artery.At different time after transplantation（after 4,8,12 and 24 weeks）,the serum ALB was detected and the ALB values of patients with different Child-Pugh score were contrasted.At the same time,the symptoms,complications and prognosis of these patients were recorded.Results Before transplantation of BM-MNCs,the mean serum ALB value of transplantation group was（29.33±3.92）g/L.The value rised to（32.37±4.63）g/L,（32.82±4.84）g/L,（32.95±5.10）g/L and（32.22±5.87）g/L,respectively after 4,8,12 and 24 weeks.Serum ALB values of patients in transplantation group after transplantation were higher than pretransplant.Serum ALB value in control group had no obvious change.In transplantation group,the improvement of serum ALB values of Child-Pugh A and B grade patients were more significant than that in the patients of Child-Pugh C grade.After autologous BM-MNCs transplantation,there were no severe adverse reactions.Conclusion Autologous BM-MNCs transplantation can improve the serum ALB values of patients with liver cirrhosisis and the improvement was more significant in the patients of Child-Pugh A and B grade.

关 键 词：骨髓单个核细胞 移植 肝硬化 白蛋白 

分 类 号：R575.2[医药卫生—消化系统]