PAK4在乳腺癌及良性乳腺病变中的表达及意义  

Expression of PAK4 in breast cancer and benign breast pathological changes

作　　者：杨金星[1] 韩宇晶[2] 郑航[1] 罗荣城[1] 

机构地区：[1]南方医科大学南方医院肿瘤中心,广东广州510515 [2]中山大学肿瘤防治中心,广东广州510060

出　　处：《南方医科大学学报》2010年第5期981-983,988,共4页Journal of Southern Medical University

基　　金：广东省科技计划项目(2008B030301144)

摘　　要：目的探讨p21活化激酶4(p21-activatedkinase-4,PAK4)在乳腺癌发病、发展及转移过程中的作用。方法采用免疫组化SP法检测35例正常乳腺组织、22例乳腺囊性增生病、28例乳房纤维腺瘤、37例乳腺癌(其中非浸润性癌7例,早期浸润癌9例,浸润癌21例)及13例乳腺癌转移瘤组织中的PAK4含量,比较各类组织中PAK4的表达特点与分布特征。结果 PAK4表达主要位于胞浆,胞核偶有少量表达,而乳腺腺体细胞外基质中基本不表达;正常乳腺组织、良性病变(乳腺囊性增生病和乳腺腺瘤)、乳腺癌和乳腺癌转移瘤组织中的PAK4表达总体阳性率依次升高;乳腺非浸润性癌、早期浸润癌、浸润癌组织中PAK4的表达阳性率亦呈依次升高趋势。结论 PAK4与乳腺癌的演进和转移密切相关,PAK4及其基因有可能成为乳腺癌诊断和治疗的新靶点。Objective To study the role of p21-activated kinase-4 （PAK4） in the occurrence, progression and metastasis of breast cancer. Method PAK4 expression was detected in 35 cases of normal breast, 22 breast cystic hyperplasia, 28 breast adenofibroma, 37 breast cancer （including 7 non-invasive cancer, 9 early invasive cancer and 21 invasive cancer） and 13 metastatic breast cancer tissues using immunohistochemistry for a comparison of PAK4 expression and distribution. Results PAK4 was expressed mainly in the cytoplasm of the cancer cells, occasionally in the cell nuclei, and virtually not expressed in the matrix surrounding the breast cells. PAK4 positivity rates increased in the order of normal breast tissues, benign changes （including breast cystic hyperplasea and breast adenoma）, breast cancer and metastatic cancer tissues; in the cancer tissues, the positivity rates increased in the order of non-invasive breast tumor, early invasive tumor and invasive tumor tissues. Conclusion PAK4 is closely correlated to the progression and metastasis of breast cancer and may become a new diagnostic and therapeutic target of breast cancer.

关 键 词：乳腺癌/发病机制 p21活化激酶4 免疫组化SP法 分子靶向治疗 

分 类 号：R737.9[医药卫生—肿瘤] R655.8[医药卫生—临床医学]