^(147)Pm内污染诱发血液和骨髓细胞适应性反应的研究  

Adaptive Response of Blood and Bone Marrow Cells in Mice Pretreated by Low Doses of Internally Deposited 147Pm

作　　者：杨淑琴[1] 朱寿彭[1] 杨占山[1] 

机构地区：[1]苏州医学院

出　　处：《工业卫生与职业病》1999年第1期17-20,共4页Industrial Health and Occupational Diseases

摘　　要：研究了低剂量钷－１４７（１４７Ｐｍ）内污染机体能否改变相继高剂量１４７Ｐｍ内污染对小鼠血液和骨髓细胞的放射损伤效应。结果发现，低剂量１４７Ｐｍ（０３７～３７Ｂｑ／ｇ体重）可诱发小鼠血液和骨髓细胞的适应性反应，使血液和骨髓细胞对相继高剂量１４７Ｐｍ引起的辐射损伤效应有了明显的抵抗力。表现为外周血淋巴细胞计数明显高于单纯高剂量注射组（Ｐ＜００５或Ｐ＜００１），骨髓细胞染色体畸变率明显低于单纯高剂量注射组（Ｐ＜００５），并且与正常对照组相比已无明显统计学差异（Ｐ＞００５）。同时，对放射性核素内污染诱导血液和骨髓细胞适应性反应的机制进行了初步的探讨。Whether low doses of internally deposited 147Pm could change the radiation damage effects of blood and bone marrow cells in mice to subsequent high doses of internally deposited 147Pm was studied.Kunming male mice were injected at4/9tail vein with low doses of 147Pm(NO3)3 of 0\^37,3\^7 and 37 Bq/g body weight.Three days later4/9the mice were injected with high/9doses of 147 Pm(NO3)3 of 18\^5 kBq/g body weight.The animals were sacrificed at 24 hrs.after the injection of high doses of 5147 Pm(NO3)3.The results showed that the blood and bone marrow cells exposed to 0\^37-37 Bq/g of 147 Pm produced an adaptive response,i\^e\^ the blood cells and bone marrow cells showed an obvious resistance to the radiation damages induced by high does of internally deposited 147 Pm.The blood lymphocytes count increased significantly( P <0\^05 or WTBXP <0\^01),and the chromosome aberration frequency of the bone marrow cells decreased significantly( P <0\^05)in comparing with pure high doses of the 147 Pm injection group.The blood lymphocytes count and the chromosome aberration frequency of the bone marrow cells showed no statistical difference in comparing with the controls( P <0\^05). At the same time,the mechanism of the adaptive response induced by internally deposited radionuclide was preliminarily analyzed.

关 键 词：钷147 适应性反应 血细胞 骨髓细胞 染色体畸变 

分 类 号：Q345[生物学—遗传学] R818.74[医药卫生—放射医学]