直肠非甾体类抗炎药对ERCP术后胰腺炎的预防作用  

Preventive effect of rectal nonsteroidal anti-inflammatory drugs for post-ERCP pancreatitis

作　　者：夏挺松[1] 刘鹏飞[1] 

机构地区：[1]江苏省江阴市人民医院消化科,214400

出　　处：《中华消化内镜杂志》2010年第6期301-302,共2页Chinese Journal of Digestive Endoscopy

摘　　要：目的观察直肠非甾体类抗炎药（NSAIDs）对ERCP术后高淀粉酶血症及胰腺炎的预防及治疗作用。方法将符合标准的患者随机分为2组，每组30例。预防组在ERCP术前30min肌注地西泮及山莨菪碱各10mg，同时给予引哚美辛栓100mg塞肛；对照组在ERCP术前30min肌注地西泮及山莨菪碱各10mg。ERCP术前及术后6h、24h测定血清淀粉酶水平。结果比较预防组和对照组ERCP术后6h、24h血清淀粉酶的活性，发现ERCP术后6h两组间血清淀粉酶分别为（367．5±268．7）U／L、（1034．2±713．5）U／L，术后24h两组间血清淀粉酶分别为（324．9±142．3）U／L、（826．8±395．7）U／L，两组问差异均有统计学意义（P〈0．05）。结论直肠NSAIDs具有预防ERCP术后高淀粉酶血症及胰腺炎的作用。Objective To investigate the preventive and therapeutic effects of nonsteroidal anti-inflammatory drugs （NSAIDs） via rectum for hyperamylasemia and pancreatitis after ERCP （ endoscopic retrograde cholangiopanereatography）. Methods Sixty patients who underwent ERCP for various reasons were randomly divided into preventive and control groups. In addition to routine diazepam （10 rag） and anisodamine （ 10 mg） given intramuscularly in both groups before ERCP, 100 mg of indometaein suppositories was administered by rectum in preventive group. Serum amylase level was measured before and 6 hours and 24 hours after the procedure. Results Serum amylase levels at 6 hours after ERCP in preventive and control groups were （367.5 ±268.7 ） U/L and （ 1034. 2 ±713.5 ） U/L, respectively （ P 〈 0.05 ）, which were （324. 9 ±142. 3 ） U/L and （826. 8 ± 395.7） U/L, respectively, at 24 hours after ERCP （P 〈 0. 05）. Condusion Rectal use of NSAIDs can prevent hyperamylasemia and acute pancreatitis induced by ERCP.

关 键 词：胰腺炎 直肠 内窥镜逆行胰胆管造影术 非甾体类抗炎药 

分 类 号：R576[医药卫生—消化系统]